硫化氢防治胃肠道缺血再灌注损伤的研究现状  

Research status of hydrogen sulfide in the prevention and treatment of gastrointestinal ischemia-reperfusion injury

作　　者：吴思雨 孙许涛[1] 曹硕 毛彩云 周淇 宋运佳 WU Si-yu;SUN Xu-tao;CAO Shuo;MAO Cai-yun;ZHOU Qi;SONG Yun-jia(School of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150000,Heilongjiang Province,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150000

出　　处：《中国临床药理学杂志》2024年第21期3171-3175,共5页The Chinese Journal of Clinical Pharmacology

基　　金：黑龙江省自然优秀青年基金资助项目(YQ2022H020);黑龙江省博士后基金资助项目(LBH-Z21080)。

摘　　要：胃肠道缺血再灌注(I/R)损伤是外科创伤患者高发病率和死亡率的主要原因。作为第3种气体信号分子,硫化氢(H_(2)S)在人体胃肠道系统发挥重要的病理生理作用。多种新型H_(2)S供体如ATB-344、AP39对胃肠道I/R损伤具有治疗价值。本文综述了H_(2)S供体对胃肠道I/R损伤保护作用及其作用机制,旨在为胃肠道I/R损伤提供新的治疗方法,以期对其临床用药提供参考。Gastrointestinal ischemia reperfusion(I/R)injury is a major cause of high morbidity and mortality in patients with surgical trauma.At present,there are few studies on gastrointestinal I/R injury,so it is particularly important to find treatment methods for gastrointestinal I/R injury.As the third gas signaling molecule,H_(2) S plays an important physiological and pathological role in the human gastrointestinal system.Recently,a variety of novel H_(2) S donors such as ATB-344 and AP39 have shown therapeutic value for gastrointestinal I/R injury.Therefore,this article reviewed the treatment of gastrointestinal I/R injury by H_(2) S donors and its mechanism of action,aiming to provide a new treatment method for gastrointestinal I/R injury,in order to provide a reference for clinical medication of gastrointestinal I/R injury.

关 键 词：硫化氢 硫化氢供体 胃肠道缺血再灌注损伤 防治 

分 类 号：R97[医药卫生—药品]