中药及其有效成分干预Wnt/β-catenin信号通路治疗前列腺癌的研究现状  

Research status of traditional Chinese medicine and its active ingredients in the treatment of prostate cancer by interfering with Wnt/β-catenin signaling pathway

作　　者：李生龙 赵永强[3] 田大成 卢刚刚 赵渊博 金广炜 龚美胜 李慧 贾云鹏[3] 梁永林 LI Sheng-long;ZHAO Yong-qiang;TIAN Da-cheng;LU Gang-gang;ZHAO Yuan-bo;JIN Guang-wei;GONG Mei-sheng;LI Hui;JIA Yun-peng;LIANG Yong-lin(College of Integrative Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Urology Department,Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu Province,China;Graduate School,Heilongjiang Academy of Chinese Medicine,Harbin 150006,Heilongjiang Province,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃中医药大学基础医学院,甘肃兰州730000 [3]甘肃省中医院泌尿外科,甘肃兰州730050 [4]黑龙江省中医药科学院研究生院,黑龙江哈尔滨150006

出　　处：《中国临床药理学杂志》2024年第21期3191-3195,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家社会科学基金资助项目(18XMZ031);甘肃省自然科学基金资助项目(22JR5RA638);甘肃省科学技术厅重点研发基金资助项目(22YF7FA101)。

摘　　要：中药及其有效成分治疗前列腺癌(PCa)具有明显优势,并可以弥补西医治疗的不足、提高患者的生活质量。本文综述了中药及其有效成分干预分泌型糖蛋白/β-连环蛋白通路治疗PCa的研究进展,总结出干预该通路防治PCa的中药有效成分(主要有黄酮类、萜类、生物碱类、酚类及其他类等化合物)和中药复方(主要有固本清源方、益肾通癃颗粒等),并探讨了上述中药及其有效成分干预该通路防治PCa的作用机制,以期为PCa的精准治疗和中医药研究应用提供一定的参考。Traditional Chinese medicine and its active ingredients have significant advantages in treating prostate cancer(PCa),and can complement the shortcomings of Western medicine,improving the quality of life for patients.This article reviews the research progress of traditional Chinese medicine and its effective ingredients in intervening in Wnt/β-catenin pathway to treat PCa,summarizing that the main effective ingredients in traditional Chinese medicine for preventing and treating PCa through this pathway are flavonoids,terpenes,alkaloids,phenols,and other compounds;the main traditional Chinese medicine formulas include Guben Qingyuanfang,Yishen Tongpang granules,etc,and discusses the mechanisms of action of these traditional Chinese medicines and their effective ingredients in intervening in this pathway to prevent and treat PCa,in order to provide a reference for the precise treatment of PCa and the application of traditional Chinese medicine research.

关 键 词：前列腺癌 分泌型糖蛋白/β-连环蛋白 信号通路 中药 有效成分 研究现状 

分 类 号：R28[医药卫生—中药学]