阿莫西林联合格列吡嗪在糖尿病合并咽喉炎治疗中的效果分析  

Analysis of the Effect of Amoxicillin Combined with Glipizide in the Treat⁃ment of Diabetes Mellitus Complicated with Pharyngitis

作　　者：王秀芬[1] 陈水专 林钦红 WANG Xiufen;CHEN Shuizhuan;LIN Qinhong(Jinjiang Hospital(Shanghai Sixth People's Hospital Fujian Hospital),Jinjiang 362200,Fujian,China)

机构地区：[1]晋江市医院(上海市第六人民医院福建医院),福建晋江362200

出　　处：《糖尿病新世界》2024年第15期98-101,共4页Diabetes New World

摘　　要：目的探究在糖尿病合并咽喉炎治疗中应用阿莫西林联合格列吡嗪的效果。方法回顾性选取2023年3月—2024年4月晋江市医院(上海市第六人民医院福建医院)收治的106例糖尿病合并咽喉炎患者的临床资料,根据不同的治疗方法分为对照组(n=53,实施阿莫西林联合二甲双胍治疗)和观察组(n=53,实施阿莫西林联合格列吡嗪治疗),比较两组血糖指标、不良反应发生率、炎症因子指标。结果治疗后,观察组空腹血糖、餐后2 h血糖水平均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6、肿瘤坏死因子-α、C反应蛋白水平均低于对照组,差异有统计学意义(P均<0.05)。结论糖尿病合并咽喉炎患者应用阿莫西林联合格列吡嗪治疗,可改善其血糖及炎症因子水平,且不良反应发生风险较低。Objective To explore the effect of amoxicillin combined with glipizide in the treatment of diabetes melli⁃tus complicated and pharyngitis.Methods The clinical data of 106 patients with diabetes mellitus complicated with pharyngitis admitted to Jinjiang Hospital(Shanghai Sixth People's Hospital Fujian Hospital)from March 2023 to April 2024 were retrospectively selected.According to different treatment methods,they were divided into control group(n=53,treated with amoxicillin combined with metformin)and observation group(n=53,treated with amoxicil⁃lin combined with glipizide).The blood glucose indexes,incidence of adverse reactions and inflammatory factor index were compared between the two groups.Results After treatment,the levels of fasting blood glucose and 2-hour post⁃prandial blood glucose in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-αand C-reactive protein in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The application of amoxicillin combined with glipizide in patients with diabetes mellitus complicated and pharyngitis can improve their blood glucose and in⁃flammatory factors levels,and the risk of adverse reactions is low.

关 键 词：阿莫西林 格列吡嗪 糖尿病 咽喉炎 血糖水平 

分 类 号：R587.2[医药卫生—内分泌]