头面部带状疱疹血清抗氧化标志物的临床意义  

Clinical significance of serum antioxidant markers in cephalofacial herpes zoster

作　　者：周倩扬 马欣欣 郑兴平 徐丽贤 张瑞丽 ZHOU Qianyang;MA Xinxin;ZHENG Xingping;XU Lixian;ZHANG Ruili(Department of Dermatology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China;Department of Basic Medical Science,Shandong Medical College,Jinan,Shandong 250002,China)

机构地区：[1]南京医科大学第二附属医院皮肤科,江苏南京210011 [2]山东医学高等专科学校医学基础部,山东济南250002

出　　处：《国际检验医学杂志》2024年第22期2694-2698,共5页International Journal of Laboratory Medicine

基　　金：南京医科大学科技发展基金项目(NMUB20210028)。

摘　　要：目的探讨血清中抗氧化标志物在头面部带状疱疹中的表达变化及其与临床严重程度和后遗神经痛(PHN)发生之间的关系。方法选取2022年1月至2023年12月在南京医科大学第二附属医院皮肤科住院的109例头面部带状疱疹(头面部组)及169例非头面部带状疱疹患者(非头面部组),以及200例无基础疾病的健康体检人员(健康对照组),比较3组的血清抗氧化标志物,包括尿酸(UA)、总胆红素(TBIL)和白蛋白(ALB)的水平,同时评估这些标志物与头面部带状疱疹临床严重程度和PHN发生的关系。结果头面部组和非头面部组血清UA、TBIL和ALB水平显著低于健康对照组(P<0.05)。头面部组血清UA、TBIL和ALB水平显著低于非头面部组(P<0.05),与疾病严重程度呈负相关性(P<0.05)。头面部组血清UA、TBIL和ALB水平是PHN发生的独立影响因素(P<0.05),且对头面部带状疱疹PHN有一定预测价值(P<0.05)。结论头面部水痘-带状疱疹病毒的再激活、急性神经损伤和PHN发生可能都与机体低抗氧化状态有关,抗氧化生物标志物UA、TBIL和ALB可能是带状疱疹的保护因子,但还需要更多的研究来阐明其潜在的机制。Objective To investigate the expression change of serum antioxidant markers in cranofacial herpes zoster and its relationship with clinical severity and postherpetic neuralgia(PHN).Methods Totally 109 cases of cranofacial herpes zoster(cranofacial group)and 169 cases of non-cranofacial herpes zoster(non-cranofacial grlup)hospitalized in the Department of Dermatology in the Second Affiliated Hospital of Nanjing Medical University and 200 cases of health check-ups without underlying diseases(healthy control group)from January 2022 to December 2023 were selected,and the serum antioxidant markers including uric acid(UA),total bilirubin(TBIL),and albumin(ALB)of the patients in the three groups group were compared.Meanwhile,the relationship between these markers and clinical severity and PHN of cranofacial herpes zoster was assessed.Results The serum levels of UA,TBIL and ALB in the cranofacial group and non-cranofacial were significantly lower than those in the healthy control group(P<0.05).Serum UA,TBIL and ALB levels in cranofacial group were significantly lower than those in non-cranofacial group(P<0.05),and were negatively correlated with disease severity(P<0.05).Serum UA,TBIL and ALB levels in cranofacial group were independent influencing factors for the occurrence of PHN(P<0.05),and had predictive value for PHN in cranofacial herpes zoster(P<0.05).Conclusion Reactivation of cranofacial herpes zoster virus,acute nerve injury and PHN may all be related to the low antioxidant status of the body,and the antioxidant biomarkers UA,TBIL and ALB may be protective factors for herpes zoster,but more studies are needed to clarify the underlying mechanisms.

关 键 词：头面部带状疱疹 血清抗氧化标志物 带状疱疹后遗神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]