血清PARP1、sTNFR1与慢性心力衰竭患者室性心律失常的相关性研究  

Correlation between serum PARP1,sTNFR1 and ventricular arrhythmias in patients with chronic heart failure

作　　者：肖玲 石媛媛 马毅凡 刘盈盈[1] XIAO Ling;SHI Yuanyuan;MA Yifan;LIU Yingying(Department of Cardiovascular Medicine,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710000,China)

机构地区：[1]西安交通大学第一附属医院心血管内科,陕西西安710000

出　　处：《国际检验医学杂志》2024年第22期2779-2783,共5页International Journal of Laboratory Medicine

摘　　要：目的探究血清聚腺苷二磷酸核糖聚合酶(PARP)1、可溶性肿瘤坏死因子受体1(sTNFR1)与慢性心力衰竭(CHF)患者室性心律失常(VA)的相关性。方法选取2021年8月至2023年2月该院收治的CHF患者117例为研究对象,作为CHF组,并根据住院期间是否发生VA,分为VA组25例和非VA组92例;另选取同期于该院进行体检的体检健康者120例作为健康组。采用酶联免疫吸附试验测定受试者血清PARP1、sTNFR1表达水平。采用Spearman法进行相关性分析;采用Logistic回归分析影响CHF患者发生VA的因素;采用受试者工作特征(ROC)曲线分析血清PARP1、sTNFR1表达水平评估CHF患者发生VA的预测价值。结果CHF组血清PARP1、sTNFR1表达水平高于健康组(P<0.05)。VA组血清PARP1、sTNFR1水平高于非VA组(P<0.05)。VA组心肌肌钙蛋白I(cTnI)高于非VA组患者,心功能分级为Ⅰ级的比例、左室射血分数、血红蛋白(Hb)低于非VA组(P<0.05)。血清PARP1、sTNFR1表达水平与cTnI、心功能分级呈正相关,与Hb、左室射血分数呈负相关(P<0.05)。Logistic回归分析结果显示,PARP1、sTNFR1是CHF患者发生VA的危险因素(P<0.05)。ROC曲线显示,血清PARP1、sTNFR1联合预测CHF患者发生VA的曲线下面积(AUC)为0.909,高于单独预测(Z PARP1-联合=2.023、P=0.043,Z sTNFR1-联合=2.077、P=0.038),其灵敏度和特异度分别为92.00%,72.83%。结论血清PARP1、sTNFR1在CHF患者血清中上调,其高表达与CHF患者发生VA密切相关,二者联合对VA的预测价值较高。Objective To investigate the correlation between serum polyadenyldiphosphate ribose polymerase(PARP)1,soluble tumor necrosis factor receptor 1(sTNFR1),and ventricular arrhythmias(VA)in patients with chronic heart failure(CHF).Methods A total of 117 CHF patients who visited the hospital from August 2021 to February 2023 were selected as the research objects,and were regarded as the CHF group.According to whether VA occurred during hospitalization,they were separated into a VA group of 25 cases and a non VA group of 92 cases.A total of 120 healthy individuals who underwent physical examinations were regarded as the healthy group.Enzyme linked immunosorbent assay was applied to determine the expression levels of serum PARP1 and sTNFR1 in the research objects.Spearman method was applied for correlation analysis.Logistic regression was applied to analyze the factors affecting the occurrence of VA in CHF patients.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum PARP1 and sTNFR1 levels in evaluating the occurrence of VA in CHF patients.Results The serum PARP1 and sTNFR1 levels in the CHF group were higher than those in the control group(P<0.05).The serum PARP1 and sTNFR1 levels in the VA group were obviously higher than those in the non VA group(P<0.05).The cardiac troponin I(cTnI)in the VA group was higher than that in the non VA group,and the proportion of heart function gradeⅠ,left ventricular ejection fraction,and hemoglobin(Hb)were lower than those in the non VA group(P<0.05).The levels of serum PARP1 and sTNFR1 were positively correlated with cTnI and cardiac function grading,but negatively correlated with Hb and left ventricular ejection fraction(P<0.05).Logistic regression analysis showed that PARP1 and sTNFR1 were risk factors for VA in CHF patients(P<0.05).ROC curve shows that the area under the curve(AUC)of the combined prediction of serum PARP1 and sTNFR1 for the occurrence of VA in CHF patients was 0.909,which was higher than those of single predictions(Z PA

关 键 词：聚腺苷二磷酸核糖聚合酶1 可溶性肿瘤坏死因子受体1 慢性心力衰竭 室性心律失常 相关性 

分 类 号：R541.61[医药卫生—心血管疾病]