妊娠期糖尿病临床预测标志物研究进展  

Advances in clinical predictive markers for gestational diabetes mellitus

作　　者：曹颖 罗孟军(综述) 龙治任(审校) CAO Ying;LUO Mengjun;LONG Zhiren(Department of Clinical Laboratory,Women and Children′s Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China/Chengdu Women and Children′s Central Hospital,Chengdu,Sichuan 610073,China;Department of Party Affairs,the Eighth People′s Hospital of Chengdu/Geriatric Hospital Affiliated to Chengdu Medical College,Chengdu,Sichuan 610503,China)

机构地区：[1]电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院检验科,四川成都610073 [2]四川省成都市第八人民医院/成都医学院附属老年医院党务部,四川成都610503

出　　处：《检验医学与临床》2024年第22期3412-3416,3421,共6页Laboratory Medicine and Clinic

基　　金：四川省成都市第五批市级财政科技项目(2021-YF05-00648-SN);四川省成都市卫生健康委员会医学科研课题(2021177)。

摘　　要：妊娠期糖尿病(GDM)作为妊娠期高血糖的主要类型,是引起不良妊娠结局和女性产后糖尿病的主要原因。口服葡萄糖耐量试验(OGTT)作为常规方法,目前仍然是诊断GDM的主要手段。但OGTT一般在孕中期、孕晚期才实施,可能错过GDM最佳的干预时机。因此,如何在孕早期及时、准确地筛选出GDM高危孕妇并给予适时干预成为预防GDM的关键。该文基于已有文献报道,概括总结了孕早期孕妇血清14种炎症因子和脂肪因子与GDM的关系,探讨这些指标预测GDM的能力,同时评估14种指标作为危险因素加入GDM早期预测模型的可能性,以期认识到孕早期血清中相关指标非正常变化可能带来的后果,为临床医生在孕早期及时、准确筛选出GDM高危人群提供支持。Gestational diabetes mellitus(GDM)as the main type of hyperglycemia during pregnancy is the main cause of adverse pregnancy outcomes and postpartum diabetes.Oral glucose tolerance test(OGTT)as a routine method is still the main means of diagnosing GDM.However,OGTT is generally performed in the second and third trimesters of pregnancy,which may miss the best opportunity for GDM intervention.Therefore,how to screen pregnant women with high risk of GDM timely and accurately in early pregnancy and give intervention timely becomes the key to prevent GDM.Based on existing literature reports,this paper summarizes the relationship between 14 serum inflammatory factors and adipokines in early pregnancy and GDM,discusses the ability of these indicators to predict GDM,and evaluates the possibility of adding 14 indicators as risk factors to the early prediction model of GDM,and hope that the readers will realize the possible consequences of abnormal changes of related serum indicators in the first trimester of pregnancy,and provide support for clinicians to timely and accurately screen high-risk groups of GDM in the first trimester.

关 键 词：妊娠期糖尿病 不良妊娠结局 口服葡萄糖耐量试验 生物标志物 预测 

分 类 号：R714.25[医药卫生—妇产科学] R446.1[医药卫生—临床医学]