血清胱抑素C联合床旁肾脏超声对脓毒症急性肾损伤患者预后情况的评估价值  

The prognostic value of serum cystatin C combined with bedside renal ultrasound in patients with sepsis⁃induced acute kidney injury

作　　者：戴成才[1] 程振兴 涂倩倩 DAI Chengcai;CHENG Zhenxing;TU Qianqian(Department of Emergency,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China;不详)

机构地区：[1]安徽医科大学第一附属医院急诊科,安徽合肥230022 [2]安徽医科大学第一附属医院消化内科,安徽合肥230022 [3]安徽医科大学第一附属医院高新院区急诊科,安徽合肥230022

出　　处：《实用医学杂志》2024年第22期3226-3231,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82100596)。

摘　　要：目的探讨血清胱抑素C(CysC)联合床旁肾脏超声对脓毒症急性肾损伤患者预后情况的评估价值。方法研究样本为安徽医科大学第一附属医院于2019年10月至2023年10月收治的134例脓毒症并发急性肾损伤患者,根据30 d内患者的预后情况,将其分为存活组(n=93)和病死组(n=41)。收集患者的临床资料,包括性别、年龄、心率、基础疾病、治疗情况、住院时间、基本生化指标、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ);检测患者肾功能指标[血肌酐(SCr)、尿素氮(BUN)]和CysC水平;通过床旁常规超声检测肾血流阻力指数(RI),并采用Cox回归分析评估脓毒症急性肾损伤患者预后不良的影响因素,并利用ROC曲线分析CysC联合床旁肾脏超声在脓毒症急性肾损伤患者预后评估中的应用价值。结果病死组患者的APACHEⅡ评分、SCr、BUN、CysC水平和RI分别为(25.14±4.39)分、(115.93±19.71)μmol/L、(13.65±2.45)mmol/L、(3.10±0.51)mg/L和(0.71±0.16),均高于存活组,差异均有统计学意义(P<0.05)。Cox回归分析显示,CysC水平和RI均是影响患者预后的重要因素(P<0.05);ROC曲线显示,CysC水平和RI的联合检测对脓毒症急性肾损伤患者的预后情况有较高的诊断效能,准确度为97.5%。结论CysC水平和床旁肾脏超声可作为脓毒症急性肾损伤患者的预后评估指标,指导临床治疗。Objective To assess the prognostic significance of serum cystatin C(CysC)in combination with bedside renal ultrasound for patients diagnosed with sepsis-induced acute kidney injury(AKI).Methods The study cohort comprised 134 patients with sepsis-induced AKI who were admitted to our hospital between October 2019 and October 2023.Based on the 30 day prognosis,the patients were categorized into a survival group(n=93)and a death group(n=41).Collected clinical data included gender,age,heart rate,underlying diseases,treat-ment modalities,duration of hospital stay,basic biochemical indicators,and Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)scores.Renal function markers such as serum creatinine(SCr),blood urea nitrogen(BUN),and cystatin C levels were measured;renal blood flow resistance index(RI)was assessed using bedside routine ultrasound.Cox regression analysis was employed to evaluate factors influencing poor prognosis in patients with sepsis-induced AKI while analyzing the prognostic assessment value of combining cystatin C with bedside renal ultrasound through ROC curves.Results The death group exhibited significantly higher APACHEⅡscores,SCr,BUN,CysC levels,and RI(all P<0.05)compared to the survival group.Cox regression analysis revealed that both CysC levels and RI were significant prognostic indicators(P<0.05).ROC curve analysis demonstrated that the combined assessment of CysC levels and RI yielded a high diagnostic accuracy of 97.5%in predicting outcomes for patients with sepsis-induced AKI.Conclusion CysC levels and bedside renal ultrasound can serve as prognostic indicators for patients with sepsis-induced acute kidney injury(AKI),thereby guiding clinical treatment.

关 键 词：血清胱抑素C 床旁超声 脓毒症 急性肾损伤 预后不良 

分 类 号：R54[医药卫生—心血管疾病]