血清胆红素与尿酸检验在冠心病鉴别诊断中的应用价值分析  

Application Value of Serum Bilirubin and Uric Acid Test in Differential Diagnosis of Coronary Heart Disease

作　　者：庄欢欢 Zhuang Huanhuan(Department of Clinical Laboratory,Suzhou Wuzhong District Hengjing Health Center,Suzhou 215103,Jiangsu Province,China)

机构地区：[1]苏州市吴中区横泾卫生院检验科,江苏苏州215103

出　　处：《中外医药研究》2024年第29期153-155,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

基　　金：甘肃省教育厅主办甘肃省高等学校创新基金项目(编号:2021B-335)。

摘　　要：目的:探讨冠心病鉴别诊断中血清胆红素、尿酸(UA)的应用价值。方法:选取2021年8月—2023年8月苏州市吴中区横泾卫生院冠心病患者80例为观察组;另选取同期体检结果正常的健康者80例为对照组。两组患者均接受生化检查。比较两组受检者及不同狭窄程度冠心病患者UA、总胆红素(TBiL)、直接胆红素(DBiL)、间接胆红素(IBiL)检查结果,采用受试者工作特征曲线分析UA、TBiL、DBiL、IBiL在冠心病中的诊断价值。结果:观察组UA水平高于对照组,TBiL、DBiL、IBiL水平均低于对照组(P<0.05)。极重度狭窄患者UA水平高于重、中、轻度狭窄患者,TBiL、DBiL水平低于重、中、轻度狭窄患者,IBiL水平低于中、轻度狭窄患者(P<0.05);重度狭窄患者UA水平高于中、轻度狭窄患者,TBiL、DBiL水平低于中、轻度狭窄患者,IBiL水平低于轻度狭窄患者(P<0.05);中度狭窄患者UA水平高于轻度狭窄患者,TBiL、DBiL、IBiL水平低于轻度狭窄患者(P<0.05)。UA、TBiL、DBiL、IBiL用于诊断冠心病的曲线下面积分别为0.951、0.856、0.832、0.843。其中UA的诊断敏感性、特异性最高。结论:冠心病鉴别诊断中通过检测患者血清胆红素与尿酸水平,可有效判断患者病情程度,从而取得更好的预后效果。Objective:To investigate the application value of serum bilirubin and uric acid(UA)in differential diagnosis of coronary heart disease.Methods:Eighty patients with coronary heart disease in Suzhou Wuzhong District Hengjing Health Center from August 2021 to August 2023 were selected as the observation group.Another eighty healthy subjects with normal physical examination results were selected as the control group.Both groups underwent biochemical examination.The results of UA,total bilirubin(TBiL),direct bilirubin(DBiL)and indirect bilirubin(IBiL)were compared between the two groups and patients with different stenosis.The diagnostic value of UA,TBiL,DBiL and IBiL in coronary heart disease was analyzed by subject working characteristic curve.Results:The UA level of observation group was higher than that of control group,and the TBiL,DBiL and IBiL levels were lower than those of control group(P<0.05).The UA levels in patients with extremely severe stenosis were higher than those in patients with severe,moderate and mild stenosis,the TBiL and DBiL levels were lower than those in patients with severe,moderate and mild stenosis,and the IBiL levels were lower than those in patients with moderate and mild stenosis(P<0.05);the UA level in patients with severe stenosis was higher than that in patients with moderate and mild stenosis,the TBiL and DBiL levels were lower than those in patients with moderate and mild stenosis,and the IBiL levels were lower than those in patients with mild stenosis(P<0.05);the UA levels in moderate stenosis patients were higher than those in mild stenosis patients,and the TBiL,DBiL and IBiL levels were lower than those in mild stenosis patients(P<0.05).The areas under the curve of UA,TBiL,DBiL and IBiL for diagnosing CHD were 0.951,0.856,0.832 and 0.843,respectively;the diagnostic sensitivity and specificity of UA were the highest.Conclusion:Detection of serum bilirubin and uric acid levels in the differential diagnosis of CHD can effectively judge the severity of the disease and achieve bette

关 键 词：血清胆红素 间接胆红素 直接胆红素 总胆红素 尿酸 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]