鸡传染性支气管炎细菌样颗粒的免疫原性  

Immunogenicity of bacterial-like particles against infectious bronchitis in chickens

作　　者：杨甜甜 盛守志 朱艳婷 盖丽丽 张鹏举[2] 丛彦龙 YANG Tiantian;SHENG Shouzhi;ZHU Yanting;GAI Lili;ZHANG Pengju;CONG Yanlong(College of Veterinary Medicine,Jilin University,Changchun 130062,China;Institute of Animal Biotechnology,Jilin Academy of Agricultural Sciences,Changchun 130033,China)

机构地区：[1]吉林大学动物医学学院,吉林长春130062 [2]吉林省农业科学院动物生物技术研究所,吉林长春130033

出　　处：《中国兽医学报》2024年第9期1898-1905,共8页Chinese Journal of Veterinary Science

基　　金：吉林省科技发展计划资助项目(20210101047JC)。

摘　　要：利用GEM-PA系统构建了表面展示传染性支气管炎病毒S1亚基的细菌样颗粒BLP-S1。免疫保护结果显示,BLP-S1可以有效诱导商品鸡产生特异性IgG和sIgA,能够有效抵御同种异源毒株的攻击,保护率可达90%。结果表明,BLP-S1有着良好的免疫原性和免疫保护性,具有开发新型传染性支气管炎疫苗的潜能。Infectious bronchitis in chickens is a serious threat to the global poultry industry.Despite the availability of commercial vaccines,the epidemic has not been effectively controlled.Therefore,the development of novel vaccines may provide new ways to prevent and control this disease.In this study,BLP-S1,a bacterium-like particle displaying the S1 subunit of infectious bronchitis virus on its surface,was constructed using the GEM-PA system.The immunoprotection results showed that BLP-S1 effectively induced the production of specific IgG and sIgA in commercial chickens and provided effective protection against a heterologous strain with a protection rate of up to 90%.This study demonstrated that BLP-S1 has good immunogenicity and immunoprotection,with the potential to develop a novel vaccine against infectious bronchitis.

关 键 词：传染性支气管炎病毒 S1基因 细菌样颗粒 免疫保护 

分 类 号：S852.65[农业科学—基础兽医学]