基于近红外脑功能成像的老年轻度认知障碍患者脑功能异常评估  

The assessment of abnormal brain function in patients with mild cognitive impairment based on fNIRS brain imaging Download Fulltext

作　　者：徐国栋[1] 江文宇[2] 张静莎 李增勇 XU Guodong;JIANG Wenyu;ZHANG Jingsha(Danyang People's Hospital of Jiangsu,Danyang,212300)

机构地区：[1]江苏省丹阳市人民医院,江苏省丹阳市212300 [2]广西壮族自治区江滨医院神经康复中心 [3]国家康复辅具研究中心 [4]北京市老年残疾人康复技术辅助器具重点实验室 [5]民政部神经功能信息与康复工程重点实验室

出　　处：《中国康复医学杂志》2024年第11期1606-1612,1643,共8页Chinese Journal of Rehabilitation Medicine

基　　金：国家重点研发计划项目(2022YFC3601200)。

摘　　要：目的:测量轻度认知障碍患者进行言语流畅性任务(verbal fluency task,VFT)期间的血流动力学反应,试图找到可以作为预测痴呆的筛查工具。方法:近红外脑功能成像(functional near-infrared spectroscopy,f NIRS)可以检测大脑中的血氧变化,从而揭示患者的脑功能活动状态,用来研究轻度认知障碍的大脑功能水平。本研究应用fNIRS评估了MCI患者和健康对照组前额叶区域的血流动力学反应。结果:发现MCI组前额叶脑区的血流动力学反应显著降低。结论:前额叶脑区血流动力学反应降低可以作为痴呆症的诊断生物标志物。Objective:To establish the haemodynamic response during the verbal fluency task(VFT)in patients with MCI and to find a screening tool that could be used as a predictor of dementia.Method:Functional near-infrared spectroscopy(fNIRS)can detect changes in blood oxygen in the brain,thus revealing the patient's functional brain activity status,and is used to study the level of brain function in MCI.We evaluated the hemodynamic response in the prefrontal and temporal regions of MCI patients and healthy controls in our study.Result:The results found a significantly reduced haemodynamic response in the prefrontal brain regions in the MCI group.Conclusion:The results suggested that a reduced haemodynamic response in the prefrontal brain regions could be used as a diagnostic biomarker for dementia.

关 键 词：轻度认知障碍 近红外脑功能成像 血流动力学反应 

分 类 号：R445[医药卫生—影像医学与核医学] R493[医药卫生—诊断学]