系统性免疫性炎症指数对慢性鼻窦炎鼻内镜术后复发的预测价值  

Analysis of the predictive value of systemic immune inflammation index in the recurrence of chronic sinusitis after endoscopic sinus surgery

作　　者：高文浩 胡玮 程杰 王璐璐 赵蕊 GAO Wenhao;HU Wei;CHENG Jie;WANG Lulu;ZHAO Rui(Department of Otolaryngology,Head and Neck Surgery,Xi'an Daxing Hospital,Xi'an,Shaanxi,China,710000)

机构地区：[1]西安大兴医院耳鼻咽喉头颈外科,陕西西安710000

出　　处：《分子诊断与治疗杂志》2024年第11期2038-2041,共4页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省重点研发计划(2020KWZ⁃022)。

摘　　要：目的探讨系统性免疫性炎症指数(SII)对慢性鼻窦炎(CRS)鼻内镜术后复发的预测价值。方法选取2021年1月至2023年6月西安大兴医院收治的CRS鼻内镜治疗患者96例,收集所有患者术前血液学指标(中性粒细胞、淋巴细胞、血小板水平),计算SII。根据患者术后随访12个月是否复发设复发组29例和未复发组67例。绘制受试者工作特性(ROC)曲线评价SII对CRS患者鼻内镜术后复发的预测价值,采用多因素Logistic逐步回归分析探讨患者复发影响因素。结果复发组患者中性粒细胞计数、SII均高于未复发组,血小板计数、淋巴细胞计数均低于未复发组,差异有统计学意义(均P<0.05)。血小板计数、中性粒细胞计数、淋巴细胞计数以及SII预测CRS患者鼻内镜术后复发的AUC(95%CI)分别为0.712(0.667~0.757)、0.750(0.705~0.795)、0.834(0.789~0.884)、0.938(0.893~0.983)。复发组年龄≥45岁、手术时间≥2 h、合并哮喘、合并变应性鼻炎、术后无综合治疗比例高于未复发组,嗜酸性粒细胞计数高于未复发组,差异有统计学意义(均P<0.05)。多因素分析显示,高嗜酸性粒细胞计数(OR=2.334,95%CI:1.370~4.011),术后无综合治疗(OR=2.502,95%CI:1.297~4.824),SII≥1012.09(OR=3.854,95%CI:1.873~7.927)是CRS患者鼻内镜术后复发的影响因素(均P<0.05)。结论术前高SII是影响CRS患者术后复发的独立预测因素,对预测CRS患者术后复发有较好价值,值得临床推广。Objective To investigate the value of systemic immune inflammation index(SII)in predicting the recurrence of chronic sinusitis(CRS)after endoscopic sinus surgery.Methods 96 patients with CRS who underwent nasal endoscopic treatment at Xi'an Daxing Hospital from January 2021 to June 2023 were included in the study.Preoperative hematological indicators,including neutrophil,lymphocyte,and platelet levels,were collected from all patients,and the SII was calculated.The patients were divided into two groups based on whether they experienced recurrence within 12 months after the operation:29 cases in the relapse group and 67 cases in the non⁃recurrence group.The predictive value of SII for postoperative recurrence in patients with CRS after nasal endoscopy was assessed using ROC analysis,and potential influencing factors were examined through multivariate logistic stepwise⁃regression analysis.Results The neutrophil count,SII,platelet count,and lymphocyte count in the relapsed group were all higher than those in the non⁃relapsed group(P<0.05).The AUC(95%CI)for predicting postoperative recurrence in CRS patients using platelet count,neutrophil count,lymphocyte count,and SII were 0.712(0.667~0.757),0.750(0.705~0.795),0.834(0.789~0.884),and 0.938(0.893~0.983),respectively.The ratio of age≥45 years,operation time≥2 hours,combined with asthma,allergic rhinitis,and no postoperative comprehensive treatment in the recurrence group was higher than that in the non⁃recurrence group,and the eosinophil count was also higher than that in the non⁃recurrence group(P<0.05).High eosinophil count(OR=2.334,95%CI:1.370~4.011),no comprehensive treatment after surgery(OR=2.502,95%CI:1.297~4.824),SII≥1012.09(OR=3.854,95%CI:1.873⁃7.927)were the influential factors of postoperative recurrence in cases with CRS(P<0.05).Conclusion A high preopera⁃tive SII serves as an independent predictor of postoperative recurrence in patients with CRS.It holds significant value in predicting postoperative recurrence in such patients and is de

关 键 词：慢性鼻窦炎 系统性免疫炎症指数 鼻内镜 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]