急性胰腺炎患者血清TFF3、NF⁃κB水平与预后的关系  

Relationship between serum TFF3 and NF⁃κB levels and prognosis in patients with acute pancreatitis

作　　者：邢斌瑜 申存毅[1] 林婷[1] 李晓宁[1] 谭文君[1] XING Binyu;SHEN Cunyi;LIN Ting;LI Xiaoning;TAN Wenjun(Department of Surgery Intensive Care Unit,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,China,710061)

机构地区：[1]西安交通大学第一附属医院外科重症医学科,陕西西安710000

出　　处：《分子诊断与治疗杂志》2024年第11期2103-2106,2111,共5页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省重点研发计划项目(2023⁃YBSF⁃421)。

摘　　要：目的分析急性胰腺炎(AP)患者血清三叶因子家族肽3(TFF3)、核转录因子⁃κB(NF⁃κB)表达水平,并探讨二者与预后的关系。方法选取2018年3月至2019年9月于西安交通大学第一附属医院进行治疗的急性胰腺炎(AP)患者243例作为研究对象,依据AP患者严重程度分为轻症AP(MAP组,n=120)、中重症AP(MSAP组,n=67)和重症AP(SAP组,n=56),收集并整理入组患者基本资料,并检测各组血清中TFF3、NF⁃κB表达水平。根据生存情况将患者分为预后良好组和预后不良组。采用Pearson法分析AP患者血清TFF3、NF⁃κB表达水平与临床指标的相关性;采用受试者工作特征曲线(ROC)分析血清TFF3、NF⁃κB对AP患者预后的预测价值。结果血清TC、TG、LDL⁃C及TNF⁃α、CRP水平、APACHEⅡ评分以及血清TFF3、NF⁃κB水平:MAP组<MSAP组<SAP组,差异有统计学意义(P<0.05);经Pearson法相关性分析,AP患者血清TFF3、NF⁃κB表达水平与TC、TG、LDL⁃C、TNF⁃α、CRP及APACHEⅡ评分均呈正相关(P<0.05)。ROC分析结果显示,血清TFF3预测AP患者预后的曲线下面积(AUC)为0.804(95%CI:0.729~0.878),血清NF⁃κB预测AP患者预后的AUC为0.715(95%CI:0.627~0.803),联合检测预测AP患者预后的AUC为0.828(95%CI:0.756~0.899)。结论随着AP患者严重程度增加,血清TFF3、NF⁃κB水平升高,两指标对AP患者预后评估具有一定预测价值,推测二者可能参与AP的发生发展。Objective To analyze the expression levels of serum trefoil factor family peptide 3(TFF3)and nuclear transcription factor⁃κB(NF⁃κB)in patients with acute pancreatitis(AP),and to explore their relationship with prognosis.Methods A total of 243 patients with acute pancreatitis(AP)who were treated at the First Affiliated Hospital of Xi'an Jiaotong University were included as the research subjects.Based on the severity of AP,the patients were divided into three groups:mild AP(MAP group,n=120),moderate and severe AP(MSAP group,n=67)and severe AP(SAP group,n=56).All patients were randomly assigned to either a survival group or a death group based on their outcomes.Basic patient data was collected,and ELISA was used to measure the levels of serum TFF3 and NF⁃κB in each group.The Pearson method was used to analyze the correlation between serum TFF3,NF⁃κB expression levels and clinical indicators in patients with AP.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum TFF3 and NF⁃κB for the prognosis of AP patients.Results The serum levels of TC,TG,LDL⁃C,TNF⁃α,CRP,the APACHEⅡscore,and the serum levels of TFF3 and NF⁃κB in the MSAP group and SAP group were higher,with the order being MAP group<MSAP group<SAP group(P<0.05).Correlation analysis was performed using the Pearson method,revealing that the expression levels of serum TFF3 and NF⁃κB in patients with AP were positively correlated with TC,TG,LDL⁃C,TNF⁃α,CRP,and APACHEⅡscores(P<0.05).The results of ROC analysis showed that the area under the curve(AUC)of serum TFF3 for predicting the prognosis of AP patients was 0.804(95%CI:0.729~0.878),the AUC of serum NF⁃κB for predicting the prognosis of AP patients was 0.715(95%CI:0.627~0.803),and the AUC of combined detection to predict the prognosis of AP patients was 0.828(95%CI:0.756~0.899).Conclusion As the severity of AP increases,the serum TFF3 and NF⁃κB levels also increase,showing predictive value for evaluating the prognosis of AP patie

关 键 词：急性胰腺炎 三叶因子家族肽3 核转录因子⁃κB 

分 类 号：R576[医药卫生—消化系统]