血清Gal⁃13、FGF⁃21水平诊断子痫前期和评估病情的价值  

The value of serum Gal⁃13 and FGF⁃21 levels in diagnosing preeclampsia and evaluating the condition

作　　者：康辉 薄耀杨 王纯静 张赞 雷晓娟 KANG Hui;BO Yaoyang;WANG Chunjing;ZHANG Zan;LEI Xiaojuan(Department of Obstetrics and Gynecology,Yan'an University Xianyang Hospital,Xianyang,Shaanxi,China,712000;Department of Gynecology,General Global Xi'an Xihang Hospital,Xi'an,Shaanxi,China,710021)

机构地区：[1]延安大学咸阳医院妇产科,陕西咸阳712000 [2]通用环球西安西航医院妇科,陕西西安710021

出　　处：《分子诊断与治疗杂志》2024年第11期2156-2160,共5页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省重点研发计划项目(2023⁃YBSF⁃519)。

摘　　要：目的观察子痫前期患者血清半乳糖凝集素⁃13(Gal⁃13)、成纤维细胞生长因子⁃21(FGF⁃21)表达情况,探讨Gal⁃13、FGF⁃21诊断子痫前期和评估病情的价值。方法纳入2020年12月至2023年10月期间延安大学咸阳医院收治95例子痫前期患者为子痫前期组,收集患者一般资料,根据病情程度分为轻度组52例和中/重度组43例;选取同期92名正常孕妇为健康对照组。采用酶联免疫吸附(ELISA)法检测血清Gal⁃13、FGF⁃21水平;采用受试者工作特征(ROC)曲线分析血清Gal⁃13、FGF⁃21水平对子痫前期的诊断价值及对子痫前期病情程度的评估价值;采用多因素Logistic回归分析子痫前期病情程度的影响因素。结果子痫前期组血清FGF⁃21水平高于健康对照组,Gal⁃13水平低于健康对照组,差异有统计学意义(P<0.05)。血清Gal⁃13、FGF⁃21水平单独及二者联合诊断子痫前期的AUC分别为0.780、0.848、0.884。中/重度组年龄>30岁比例、体质量指数>23 kg/m^(2)比例及血清FGF⁃21水平高于轻度组,Gal⁃13水平低于轻度组,差异有统计学意义(P<0.05)。血清Gal⁃13、FGF⁃21水平单独及二者联合评估子痫前期病情程度的AUC分别为0.856、0.784、0.919。Gal⁃13>9.39 ng/mL是子痫前期病情程度发展为中/重度的保护因素(P<0.05),FGF⁃21>270.76μg/L是子痫前期病情程度发展为中/重度的独立危险因素(P<0.05)。结论子痫前期患者血清Gal⁃13水平降低,FGF⁃21水平升高,二者联合检测可有效诊断子痫前期,同时可对疾病程度进行评估。Objective To observe the expression of serum galectin⁃13(Gal⁃13)and fibroblast growth factor⁃21(FGF⁃21)in patients with preeclampsia and explore the value of Gal⁃13 and FGF⁃21 in diag⁃nosing preeclampsia and evaluating the condition of preeclampsia.Methods A total of 95 patients with preeclampsia admitted to Xianyang Hospital of Yan'an University from December 2020 to October 2023 were included in the preeclampsia group.The general data of patients were collected,and patients were divided into a mild group(52 cases)and a moderate/severe group(43 cases)according to the severity of the disease.Meanwhile,92 normal pregnant women were selected for the healthy control group.The levels of Gal⁃13 and FGF⁃21 in serum were detected using enzyme⁃linked immunosorbent assay(ELISA).The diagnostic value of serum Gal⁃13 and FGF⁃21 levels in preeclampsia,and the evaluation value for the severity of preeclampsia,were ana lyzed using the ROC curve.Multivariate logistic regression analysis was applied to examine the influencing factors of the severity of preeclampsia.Results The serum FGF⁃21 level in the preeclampsia group was higher than that in the healthy control group,while the serum Gal⁃13 level was lower than that in the healthy control group,the difference is statistically significant(P<0.05).The AUC for diagnosing preeclampsia using serum Gal⁃13 and FGF⁃21 levels alone or in combination was 0.780,0.848,and 0.884,respectively.The proportions of individuals over 30 years old,with a body mass index>23 kg/m^(2),with moderate/severe preeclampsia were higher than those in the mild group.The level of Gal⁃13 was lower compared to the in mild group.These differences are statistically significant(P<0.05).The AUC for serum Gal⁃13 and FGF⁃21 levels in evaluating the severity of preeclampsia was 0.856,0.784,and 0.919,respectively.Gal⁃13>9.39 ng/mL was found to be a protective factor for the severity of preeclampsia progressing to moderate/severe(P<0.05),while an FGF⁃21>270.76μg/L was identified

关 键 词：子痫前期 半乳糖凝集素⁃13 成纤维细胞生长因子⁃21 

分 类 号：R714.244[医药卫生—妇产科学]