丹参川芎嗪联合替罗非班治疗急性脑梗死的效果及对脑部血流动力学的影响  

Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride combined with tirofiban in the treatment of acute cerebral infarction and its influence on cerebral hemodynamics

作　　者：屈改艳 郑婷婷 QU Gaiyan;ZHENG Tingting(Neurology Department,People's Hospital of Dingbian County,Yulin 719000;Neurology Department,Hanbin District Third People's Hospital,Ankang 725000,China)

机构地区：[1]榆林市定边县人民医院神经内科,陕西榆林719000 [2]安康市汉滨区第三人民医院神经内科,陕西安康725000

出　　处：《临床医学研究与实践》2024年第32期159-162,共4页Clinical Research and Practice

摘　　要：目的探讨丹参川芎嗪联合替罗非班治疗急性脑梗死的效果及对脑部血流动力学的影响。方法选取2022年1月至12月收治的88例急性脑梗死患者为研究对象,根据入院时间将其分为对照组与观察组,各44例。对照组给予替罗非班治疗,观察组在对照组基础上加丹参川芎嗪治疗。比较两组的临床疗效、脑部血流动力学指标及神经功能指标。结果观察组的治疗总有效率为90.91%,高于对照组的72.73%,差异具有统计学意义(P<0.05)。治疗后,观察组的大脑中动脉(MCA)血流速度及脑血容量(CBV)高于对照组,动态阻力(DR)及阻力指数(RI)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的胶质纤维酸性蛋白(GFAP)水平低于对照组,神经生长因子(NGF)及脑源性神经营养因子(BDNF)水平高于对照组,差异具有统计学意义(P<0.05)。结论丹参川芎嗪联合替罗非班治疗急性脑梗死不仅能够提升临床效果,还能改善脑部血流动力学,促进神经功能恢复,值得推广。Objective To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride combined with tirofiban in the treatment of acute cerebral infarction and its influence on cerebral hemodynamics.Methods A total of 88 patients with acute cerebral infarction admitted from January to December 2022 were selected as the research objects.According to the admission time,the patients were divided into control group and observation group,with 44 cases in each group.The control group was treated with tirofiban,and the observation group was treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride on the basis of the control group.The clinical efficacy,cerebral hemodynamic indexes and neurological function indexes of the two groups were compared.Results The total effective rate of treatment in the observation group was 90.91%,which was higher than 72.73%in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood flow velocity of middle cerebral artery(MCA)and cerebral blood volume(CBV)in the observation group were higher than those in the control group,and the dynamic resistance(DR)and resistance index(RI)were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the level of glial fibrillary acidic protein(GFAP)in the observation group was lower than that in the control group,and the levels of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride combined with tirofiban in the treatment of acute cerebral infarction can not only improve the clinical effect,but also improve cerebral hemodynamics and promote the recovery of neurological function,which is worthy of promotion.

关 键 词：丹参川芎嗪 替罗非班 急性脑梗死 脑部血流动力学 神经功能 

分 类 号：R277.7[医药卫生—中医学]