Altered Cortical Information Interaction During Respiratory Events in Children with Obstructive Sleep Apnea-Hypopnea Syndrome  

作　　者：Jin Chen Minmin Lin Naikai Shi Jingxian Shen Xuchu Weng Feng Pang Jiuxing Liang 

机构地区：[1]Key Laboratory of Brain,Cognition and Education Science,Ministry of Education,China,Institute for Brain Research and Rehabilitation,Guangdong Key Laboratory of Mental Health and Cognitive Science,South China Normal University,Guangzhou 510631,China [2]School of General Education,Guangzhou Huali College,Guangzhou 511325,China [3]Department of Sleep Medicine,The Sixth Affliated Hospital,Sun Yat-sen University,Guangzhou 510655,China [4]Department of Otorhinolaryngology,Head and Neck Surgery,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China [5]TUM-Neuroimaging Center,Technical University of Munich,81675 Munich,Germany [6]Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument,Sun Yat-Sen University,Guangzhou 510006,China [7]Biomedical Innovation Center,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China

出　　处：《Neuroscience Bulletin》2024年第10期1458-1470,共13页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (82001919);the Guangdong Basic and Applied Basic Research Foundation (2022A1515010050);the China Postdoctoral Science Foundation (2022M711219);the Key Realm R&D Program of Guangdong Province (2019B03035001);the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments (2020B1212060077).

摘　　要：Obstructive sleep apnea-hypopnea syndrome(OSAHS)significantly impairs children's growth and cognition.This study aims to elucidate the pathophysiological mechanisms underlying OSAHS in children,with a particular focus on the alterations in cortical information interaction during respiratory events.We analyzed sleep electroencephalography before,during,and after events,utilizing Symbolic Transfer Entropy(STE)for brain network construction and information flow assessment.The results showed a significant increase in STE after events in specific frequency bands during N2 and rapid eye movement(REM)stages,along with increased STE during N3 stage events.Moreover,a noteworthy rise in the information flow imbalance within and between hemispheres was found after events,displaying unique patterns in central sleep apnea and hypopnea.Importantly,some of these alterations were correlated with symptom severity.These findings highlight significant changes in brain region coordination and communication during respiratory events,offering novel insights into OSAHS pathophysiology in children.

关 键 词：Obstructive sleep apnea-hypopnea syndrome CHILDREN Respiratory events ELECTROENCEPHALOGRAM Effective connectivity-Symbolic transfer entropy 

分 类 号：R338[医药卫生—人体生理学]