Deletion of Luzp Does Not Cause Hearing Loss in Mice  

作　　者：Cheng Cheng Guangjie Zhu Kaijian Wang Chuan Bu Siyu Li Yue Qiu Jie Lu Xinya Ji Wenli Hao Junguo Wang Chengwen Zhu Ye Yang Yajun Gu Xiaoyun Qian Chenjie Yu Xia Gao 

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,Drum Tower Hospital,Affiliated Hospital of the Medical School,Jiangsu Provincial Key Medical Discipline(Laboratory),Nanjing University,Nanjing 210008,China [2]Research Institute of Otolaryngology,Nanjing 210008,China [3]Department of Otorhinolaryngology,Qidong People's Hospital,Qidong Liver Cancer Institute,Affliated Qidong Hospital of Nantong University,Nantong 226200,China [4]The First Affiliated Hospital of Kangda College of Nanjing Medical University,The First People's Hospital of Lianyungang,Lianyungang 222000,China [5]Northern Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou 225001,China

出　　处：《Neuroscience Bulletin》2024年第10期1519-1528,共10页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (81970884,81900941,81970885,82371157,82171145,82271173,and 81771019);the Natural Science Foundation of Jiangsu Province (BK20190121 and BK20200133);the China Postdoctoral Science Foundation (2020M681555);a Distinguished Young Scholarship supported by the Medical Science and Technology Development Foundation,Nanjing Department of Health (JQX20003).

摘　　要：Deafness is the prevailing sensory impairment among humans,impacting every aspect of one's existence.Half of congenital deafness cases are attributed to genetic factors.Studies have shown that Luzp2 is expressed in hair cells(HCs)and supporting cells of the inner ear,but its specific role in hearing remains unclear.To determine the importance of Luzp2 in auditory function,we generated mice deficient in Luzp2.Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells.However,the loss of Luzp2 did not result in any changes in auditory threshold.HCs or synapse number and HC stereocilia morphology in Luzp2 knockout mice did not show any notable distinctions.This was the first study of the role of Luzp2 in hearing in mice,and our results provide important guidance for the screening of deafness genes.

关 键 词：Hearing loss Luzp2 Hair cell Stereocilia Ribbon synapse 

分 类 号：R764[医药卫生—耳鼻咽喉科]