A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System  

作　　者：Zexuan Ma Wei Zhang Chenmeng Wang Yixun Su Chenju Yi Jianqin Niu 

机构地区：[1]Department of Histology and Embryology,College of basic medicine,Third Military Medical University,Chongqing 400038,China [2]Research Centre,Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518107,China [3]Guangdong Provincial Key Laboratory of Brain Function and Disease,Guangzhou,China [4]Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research,Shenzhen 518107,China [5]Chongqing Key Laboratory of Neurobiology,Chongqing 400038,China

出　　处：《Neuroscience Bulletin》2024年第10期1573-1589,共17页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (32271034,32070964,81971309,32170980,and 32300791);National Key Research and Development Program of China (2021ZD0201703);Chongqing Natural Science Fund for Distinguished Young Scholars (CSTB2023NSCQ-JQX0030);Guangdong Basic and Applied Basic Research Foundation (2022B1515020012,2021A1515110268,2023A1515010651);Shenzhen Medical Research Fund (A2303014);Shenzhen Fundamental Research Program (JCYJ20210324123212035,RCYX20200714114644167,ZDSYS20220606100801003,RCBS20210706092411028,and JCYJ20210324121214039);Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research (ZDSYS20220606100801003).

摘　　要：Oligodendrocyte precursor cells(OPCs)are a heterogeneous multipotent population in the central nervous system(CNS)that appear during embryogenesis and persist as resident cells in the adult brain parenchyma.OPCs could generate oligodendrocytes to participate in myelination.Recent advances have renewed our knowledge of OPC biology by discovering novel markers of oligodendroglial cells,the myelin-independent roles of OPCs,and the regulatory mechanism of OPC development.In this review,we will explore the updated knowledge on OPC identity,their multifaceted roles in the CNS in health and diseases,as well as the regulatory mechanisms that are involved in their developmental stages,which hopefully would contribute to a further understanding of OPCs and attract attention in the field of OPC biology.

关 键 词：Oligodendrocyte precursor cell OPC-neuron synapse-Myelin-independent roles Heterogeneity:Migration Proliferation Differentiation 

分 类 号：R338[医药卫生—人体生理学]