升阳健脾调肝汤治疗腹泻型肠易激综合征肝郁脾虚证40例  

Clinical effect of Shengyang Jianpi Tiaogan decoction in treatment of diarrhea-predominant irritable bowel syndrome with liver depression and spleen deficiency:An analysis of 40 cases

作　　者：李金斗 夏建东[1] 梁邦杰 李怡萱 LI Jindou;XIA Jiandong;LIANG Bangjie;LI Yixuan(Taicang Hospital of Traditional Chinese Medicine,Taicang 215400,Jiangsu,China)

机构地区：[1]太仓市中医医院,江苏太仓215400

出　　处：《湖南中医杂志》2024年第10期9-11,38,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：江苏省苏州市卫生青年骨干人才“全国导师制”培训项目(Qngg2022050)。

摘　　要：目的:观察升阳健脾调肝汤治疗腹泻型肠易激综合征(IBS-D)肝郁脾虚证的临床疗效。方法:选取IBS-D肝郁脾虚证患者80例,按随机数字表法分为治疗组和对照组,每组各40例。治疗组采用升阳健脾调肝汤治疗,对照组采用马来酸曲美布汀片和双歧三联活菌胶囊治疗,疗程均为4周。观察2组治疗前后中医证候积分的变化,评价中医证候疗效,记录不良反应。结果:治疗后中医证候疗效总有效率治疗组为92.50%(37/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);停药后28 d随访,中医证候疗效总有效率治疗组为85.00%(34/40),高于对照组的67.50%(27/40),差异有统计学意义(P<0.01)。2组中医证候总积分治疗前后组内比较及治疗14 d、28 d组间比较,差异均有统计学意义(P<0.01);2组均无明显不良反应发生。结论:升阳健脾调肝汤治疗IBS-D肝郁脾虚证的临床疗效优于西药马来酸曲美布汀和双歧三联活菌胶囊治疗,且有良好安全性。Objective:To investigate the clinical effect of Shengyang Jianpi Tiaogan decoction in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D)with liver depression and spleen deficiency.Methods:A total of 80 IBS-D patients with liver depression and spleen deficiency were divided into treatment group and control group using a random number table,with 40 patients in each group.The patients in the treatment group received Shengyang Jianpi Tiaogan decoction,while those in the control group received trimebutine maleate tablets and Bifid-triple viable capsules,and the course of treatment was 4 weeks for both groups.The two groups were compared in terms of the change in traditional Chinese medicine(TCM)syndrome score after treatment,the treatment outcome of TCM syndrome was assessed,and adverse events were recorded.Results:The treatment group had a significantly higher overall response rate of TCM syndrome than the control group after treatment[92.50%(37/40)vs 77.50%(31/40),P<0.05],and follow-up on day 28 after drug withdrawal showed that the treatment group still had a significantly higher overall response rate of TCM syndrome than the control group[85.00%(34/40)vs 67.50%(27/40),P<0.01].Both groups had a significant change in total TCM syndrome score on days 14 and 28 of treatment,and there was a significant difference between the two groups(P<0.01),with little adverse effect in either group.Conclusion:Shengyang Jianpi Tiaogan decoction has a better clinical effect than the Western medicine drugs trimebutine maleate tablets and Bifid-triple viable capsules in the treatment of IBS-D with liver depression and spleen deficiency,with a favorable safety profile.

关 键 词：腹泻型肠易激综合征 肝郁脾虚证 升阳健脾调肝汤 

分 类 号：R259.744[医药卫生—中西医结合]