红细胞输注联合促红细胞生成素治疗肾性贫血的效果研究  

Therapeutic effect of red blood cell transfusion combined with erythropoietin on renal anemia

作　　者：李占伟[1] 张琳 韩丹 Li Zhanwei;Zhang Lin;Han Dan(Department of Blood Transfusion,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Department of Clinical Laboratory,Luoyang Cuiyun Road Community Healthcare Service Center,Luoyang 471000,China;Department of Clinical Laboratory,Luoyang Orthopedics Hospital,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院输血科,洛阳471000 [2]洛阳市翠云路社区卫生服务中心检验科,洛阳471000 [3]洛阳市正骨医院检验科,洛阳471000

出　　处：《中国实用医刊》2024年第19期34-37,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析红细胞输注联合促红细胞生成素治疗肾性贫血的效果。方法队列研究。抽取2021年3月至2022年12月河南科技大学第一附属医院收治的慢性肾病贫血患者70例,按照随机数字表法分为观察组和对照组,每组35例。对照组患者仅进行红细胞输注治疗,观察组患者在红细胞输注治疗的基础上联合促红细胞生成素进行治疗。比较两组治疗效果、输血指标(输血间隔时间、输血量)、证候积分、血液指标[血细胞比容(Hct)、血红蛋白(Hb)、红细胞计数(RBC)]及不良反应。结果观察组治疗总有效率(94.29%,33/35)高于对照组(77.14%,27/35),P<0.05。观察组输血间隔时间长于对照组,平均输血量少于对照组(P<0.05)。治疗后,观察组食少纳呆、倦怠乏力、腰膝酸软评分均低于对照组(P均<0.05);治疗后,观察组Hct、Hb、RBC水平均高于对照组(P均<0.05)。观察组不良反应发生率(8.57%,3/35)低于对照组(28.57%,10/35),P<0.05。结论促红细胞生成素联合红细胞输注治疗慢性肾病贫血可提高治疗效果,延长输血间隔时间,减少输血量,减轻临床症状,改善贫血状况,降低不良反应发生率。ObjectiveTo analyze the effect of red blood cell transfusion combined with erythropoietin in the treatment of renal anemia.MethodsSeventy patients with anemia of chronic renal disease treated in the First Affiliated Hospital of Henan University of Science and Technology from March 2021 to December 2022 were selected for the cohort study.And they were divided into an observation group and a control group by random number table method,with 35 cases in each group.The control group was treated with red blood cell transfusion,while the observation group was treated with erythropoietin on the basis of red blood cell transfusion.The treatment efficacy,blood transfusion indexes(transfusion interval time,blood transfusion volume),syndrome scorse,blood indexes including hematocrit(Hct),hemoglobin(Hb)and red blood cell count(RBC),and incidence of adverse reactions of the two groups were compared.ResultsThe total effective rate of the observation group(94.29%,33/35)was higher than that of the control group(77.14%,27/35),P<0.05.The observation group had longer transfusion interval time and less transfusion volume compared with the control group(P<0.05).After treatment,the scores of appetite loss,fatigue,and waist-knee soreness and softness in the observation group were lower than those in the control group(all P<0.05).After treatment,the levels of Hct,Hb,and RBC in the observation group were higher than those in the control group(all P<0.05).The incidence of adverse reactions in the observation group(8.57%,3/35)was lower than that in the control group(28.57%,10/35),P<0.05.ConclusionsErythropoietin combined with red blood cell transfusion in the treatment of anemia of chronic renal disease can improve the therapeutic effect,prolong the transfusion interval time,reduce the transfusion volume,relieve clinical symptoms,alleviate anemia,and reduce the incidence of adverse reactions.

关 键 词：促红细胞生成素 慢性肾病贫血 红细胞输注 

分 类 号：R692[医药卫生—泌尿科学] R556[医药卫生—外科学]