肾衰宁颗粒联合连续性血液透析对肾衰患者炎症反应、残余肾功能及结缔组织生长因子表达的研究  

Study of continuous hemodialysis combined with Shenshuaining Granule on inflammatory response,residual renal function and CTGF expression in patients with renal failure

作　　者：牟筱倩 蔡威巍 于颖吉 陈奕纬 MU Xiaoqian;CAI Weiwei;YU Yingji;CHEN Yiwei(Kidney Internal Medicine,Huangpu Branch of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China;Department of Cardiology,Huangpu Branch of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院黄浦分院肾脏内科,上海200011 [2]上海交通大学医学院附属第九人民医院黄浦分院心内科,上海200011

出　　处：《药物评价研究》2024年第10期2388-2394,共7页Drug Evaluation Research

摘　　要：目的 探讨肾衰宁颗粒联合连续性血液透析对肾衰患者炎症反应、残余肾功能及结缔组织生长因子(CTGF)表达的影响。方法 选取2022年7月-2023年7月在上海交通大学医学院附属第九人民医院黄浦分院就诊的200例肾衰患者,随机将其分为对照组和试验组,每组各100例,两组患者均进行连续性血液透析治疗,试验组在此基础上给予肾衰宁颗粒治疗,每次1袋,每天3次,治疗3个月。观察两组炎症反应、残余肾功能及CTGF表达等情况。结果 试验组总有效率(94.00%)明显高于对照组(71.00%),组间比较差异显著(P<0.05)。治疗前两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、核因子κB抑制蛋白-α(IκB-α)水平对比无明显差异;治疗后,两组IL-6、TNF-α、IκB-α水平均显著降低(P<0.05),且试验组比对照组降低明显(P<0.05)。治疗前两组血肌酐(SCr)、血胱抑素-C(CCys-C)、肾小球滤过率(GFR)水平对比无明显差异;治疗后,两组SCr、CCys-C、GFR水平均显著降低(P<0.05),且试验组明显低于对照组(P<0.05)。治疗前两组CTGF表达对比无明显差异;治疗后,两组CTGF表达显著降低(P<0.05),且试验组比对照组降低明显(P<0.05)。试验组总不良反应率(5.00%)明显低于对照组(13.00%),组间差异有统计学意义(P<0.05)。结论肾衰宁颗粒联合连续性血液透析对肾衰患者具有显著疗效,其可显著改善炎症反应,提高残余肾功能,并显著抑制CTGF表达。Objective To explore the study of continuous hemodialysis combined with Shenshuaining Granule on inflammatory response,residual renal function and connective tissue growth factor(CTGF)expression in renal failure patients.Methods From July 2022 to July 2023,200 patients with renal failure who attended the Huangpu branch of the Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine were selected and randomly divided into control group and experimental group,100 cases in each group,and both groups were treated with continuous hemodialysis,and the experimental group was given Shenshuaining Granule on the basis of which,one sachet per time,three times per day,treatment for three months.Observe the inflammatory reaction,residual renal function and CTGF expression in both groups.Results Compared with the control group,the total effective rate of the experimental group(94.00%)was significantly higher than that of the control group(71.00%),and the difference between the groups was obvious(P<0.05).There was no significant difference in the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and nuclear factorκB inhibitory protein-α(IκB-α)between the two groups before treatment;after treatment,the levels of IL-6,TNF-α,and IκB-αin the two groups were significantly reduced(P<0.05),and the experimental group was reduced significantly compared with the control group(P<0.05).There was no significant difference in the comparison of blood creatinine(SCr),blood cystatin-C(CCys-C),and glomerular filtration rate(GFR)levels between the two groups before treatment;after treatment,the levels of SCr,CCys-C,and GFR in the two groups were significantly reduced(P<0.05),and the experimental group was significantly lower than the control group(P<0.05).There was no significant difference in the comparison of CTGF expression between the two groups before treatment;after treatment,CTGF expression was significantly reduced in both groups(P<0.05),and the test group was significantly lower than the c

关 键 词：连续性血液透析 肾衰宁颗粒 肾衰 炎症反应 残余肾功能 结缔组织生长因子 

分 类 号：R976[医药卫生—药品]