响应面试验优化金银花浸膏的真空带式干燥工艺研究  

Optimization of vacuum belt drying process for Lonicerae Japonicae Flos extract by response surface test

作　　者：郭田甜 杨本官 张丽萍 房兆营 孙艳 庄会芳 刘震远 马庆文 毕艳艳 王永刚 GUO Tiantian;YANG Benguan;ZHANG Liping;FANG Zhaoying;SUN Yan;ZHUANG Huifang;LIU Zhenyuan;MA Qingwen;BI Yanyan;WANG Yonggang(State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China;Lunan Houpu Pharmaceutical Co.,Ltd.,Linyi 276000,China;Shandong Province Traditional Chinese Medicine Pharmaceutical Common Technology Engineering Laboratory,Linyi 276000,China;Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China;Lunan Beite Pharmaceutical Co.,Ltd.,Linyi 276000,China)

机构地区：[1]鲁南制药集团经方与现代中药融合创新全国重点实验室,山东临沂276000 [2]鲁南厚普制药有限公司,山东临沂276000 [3]中药制药共性技术山东省工程研究中心,山东临沂276000 [4]鲁南制药集团股份有限公司,山东临沂276000 [5]鲁南贝特制药有限公司,山东临沂276000

出　　处：《现代药物与临床》2024年第10期2521-2526,共6页Drugs & Clinic

基　　金：山东省重点研发计划(重大科技创新工程)(2021CXGC010508);临沂市兰山区科技创新发展计划(2105)。

摘　　要：目的优化金银花浸膏的真空带式干燥工艺。方法将单因素试验和响应面试验法结合,确定考察金银花浸膏的相对密度、第2段加热温度、履带速率和布料速度4个影响因素,以金银花干浸膏的水分和绿原酸转移率的综合评分作为考察指标,对金银花浸膏的真空带式干燥工艺参数进行优化。结果最优化工艺参数为第2段加热温度为90℃、浸膏相对密度为1.27、履带速率110 mm/min,布料速度为1.6 L/h。结论所得工艺耗时短、效率高,工艺稳定,可操作性强,为金银花工业化生产提供了参考。Objective To optimize of vacuum belt drying process for Lonicerae Japonicae Flos extract.Methods Single factor test combined with response surface tests were used.Four influencing factors as relative density of extract,two-stage heating temperature,track speed,and distribution speed were confirmed,and the comprehensive score of moisture content and chlorogenic acid transfer rate was used as the evaluation index to optimize of vacuum belt drying process.Results The optimized process parameters were as following:the two-stage heating temperature was 90℃,the relative extract density was 1.27,the track speed was 110 mm/min,and the distribution speed was 1.6 L/h.Conclusion The obtained process has short time consumption,high efficiency,stable process,and strong operability,providing a reference for the industrial production of Lonicerae Japonicae Flos.

关 键 词：金银花提取物 带式真空干燥 水分 绿原酸转移率 响应面试验 

分 类 号：R283[医药卫生—中药学]