湿润烧伤膏联合复方磺胺嘧啶锌凝胶治疗头面部烧伤的临床研究  

Clinical study on with Shirun Shaoshang Ointment combined with Compound Sulfadiazine Zinc Gel in treatment of head and facial burns

作　　者：陈越 孟艳斌 白培懿 任锋 CHEN Yue;MENG Yanbin;BAI Peiyi;REN Feng(No.2 Department of Burn,Taiyuan Iron and Steel(Group)Co.,Ltd.,General Hospital,Taiyuan 030009,China;Shanxi University of Traditional Chinese Medicine,Taiyuan 030619,China)

机构地区：[1]太原钢铁(集团)有限公司总医院烧伤二科,山西太原030009 [2]山西中医药大学,山西太原030619

出　　处：《现代药物与临床》2024年第10期2621-2624,共4页Drugs & Clinic

基　　金：山西省卫生计生委科研课题项目(2015104)。

摘　　要：目的探讨湿润烧伤膏联合复方磺胺嘧啶锌凝胶治疗头面部烧伤的临床疗效。方法选择2020年3月—2023年12月在太原钢铁(集团)有限公司总医院就诊的82例头面部烧伤患者,按随机数字表法将所有患者分为对照组和治疗组,每组各41例。对照组涂抹复方磺胺嘧啶锌凝胶厚度0.15~0.35 mm,1次/d;治疗组涂抹复方磺胺嘧啶锌凝胶与湿润烧伤膏1∶3混合物厚度约1 mm。两组持续治疗14 d。评估两组的总有效率、主观疼痛程度和凝血功能指标。结果治疗组的总有效率为82.93%,对照组的总有效率为63.41%,两组组间比较差异显著(P<0.05)。治疗后,两组的视觉模拟评分法(VAS)评分均显著降低(P<0.05),且治疗组的VAS评分较对照组更低(P<0.05)。治疗后,两组的纤维蛋白原(FIB)、D-二聚体(D-D)水平低于治疗前,血小板计数(PTL)水平高于治疗前(P<0.05);治疗组的FIB、D-D水平低于对照组,PTL水平高于对照组(P<0.05)。结论湿润烧伤膏联合复方磺胺嘧啶锌凝胶可提高头面部烧伤的临床疗效,进一步减轻疼痛程度,改善凝血功能。Objective To investigate the efficacy of Shirun Shaoshang Ointment combined with Compound Sulfadiazine Zinc Pingment in treatment of head and facial burns.Methods 82 Patients with head and facial burns in Taiyuan Iron and Steel(Group)Co.,Ltd.,General Hospital from March 2020 to December 2023 were divided into control and treatment group by random number table method,with 41 cases per group.Patients in the control group were treated with Compound Sulfadiazine Zinc Gel with a thickness of 0.15—0.35 mm,once daily.Patients in the treatment group applied a 1:3 mixture of Compound Sulfadiazine Zinc Gel and Shirun Shaoshang Ointment with a thickness of about 1 mm.Patients in both groups were treated for 14 d.The total effective rate,subjective pain degree,and coagulation function of the two groups were evaluated.Results The total effective rate was 82.93%in the treatment group,and 63.41%in the control group,and the difference between two groups was significant(P<0.05).After treatment,VAS scores of two groups were significantly decreased(P<0.05),and VAS scores of the treatment group were lower than those in the control group(P<0.05).After treatment,FIB and D-D levels of two groups were lower than those before treatment,but PTL levels of two groups were higher than those before treatment(P<0.05).FIB and D-D levels in the treatment group were lower than those in the control group,but PTL levels were higher than those in the control group(P<0.05).Conclusion The combination of Shirun Shaoshang Ointment and Compound Sulfadiazine Zinc Gel can improve the efficacy of head and facial burns,further reduce pain,and improve coagulation function.

关 键 词：湿润烧伤膏 复方磺胺嘧啶锌凝胶 头面部烧伤 VAS评分 纤维蛋白原 D-二聚体 血小板计数 

分 类 号：R986[医药卫生—药品]