重楼皂苷逆转肿瘤多药耐药的研究进展  

Research progress on reversing tumor multidrug resistance of polyphyllins

作　　者：朱翔 李畏娴 王俊龙 陈洁 ZHU Xiang;LI Weixian;WANG Junlong;CHEN Jie(Department of Pharmacy,Kunming Third People’s Hospital,Kunming 650041,China)

机构地区：[1]昆明市第三人民医院药学部,云南昆明650041

出　　处：《现代药物与临床》2024年第10期2704-2710,共7页Drugs & Clinic

基　　金：云南省科技厅重大专项(202302AG05);昆明市卫生科技人才医学科技后备人才项目[2023-SW(后备)-49]。

摘　　要：肿瘤多药耐药的出现是化疗失败的主要原因之一。甾体皂苷是重楼中主要活性成分,目前已鉴定分离出重楼皂苷Ⅰ、Ⅱ、Ⅶ、D等。重楼皂苷通过抑制药物外排、诱导细胞凋亡、抑制细胞自噬、调控细胞周期、调控相关信号通路等多途径、多靶点逆转肿瘤耐药。综述了重楼皂苷逆转肿瘤耐药机制的研究进展,为肿瘤耐药逆转剂的新药研发提供参考。The emergence of multidrug resistance in tumors is one of the main reasons for chemotherapy failure.Steroid saponins are the main active ingredients in Paridis Rhizoma,and have been isolated and identified as polyphyllin Ⅰ,Ⅱ,Ⅶ,D,etc.Polyphyllins reverse tumor multidrug resistance through multiple pathways and targets,such as inhibiting drug efflux,inducing cell apoptosis,inhibiting autophagy,regulating cell cycle,and regulating related signaling pathways.This article reviews the research progress on mechanism of polyphyllins reversing tumor multidrug resistance,providing reference for the development of new drugs for reversing tumor multidrug resistance agents.

关 键 词：重楼皂苷 重楼皂苷Ⅰ 重楼皂苷Ⅱ 重楼皂苷Ⅶ 重楼皂苷D 肿瘤多药耐药 药物外排 细胞凋亡 细胞自噬 细胞周期 信号通路 

分 类 号：R979.1[医药卫生—药品]