津力达颗粒联合司美格鲁肽对2型糖尿病合并颈动脉粥样硬化患者糖脂代谢、炎性标记物及动脉硬化指标的影响  

Effects of Jinlida Granules Combined with Semeglutide on Glycolipid Metabolism,Inflammatory Markers and Arteriosclerosis Indexes in Patients with Type 2 Diabetes Mellitus Combined with Carotid Atherosclerosis

作　　者：魏伟 张海生 徐晶晶 李婷婷 张敏 WEI Wei;ZHANG Hai-sheng;XU Jing-jing;LI Ting-ting;ZHANG Min(Department of Endocrinology,Shanxi University of Traditional Chinese Medicine Affiliated Hospital,Taiyuan,Shanxi,030024,China)

机构地区：[1]山西中医药大学附属医院内分泌科,山西太原030024

出　　处：《现代生物医学进展》2024年第20期3923-3925,共3页Progress in Modern Biomedicine

基　　金：山西省中医药管理局科研项目(2020ZYYC033)。

摘　　要：目的:观察2型糖尿病(T2DM)合并颈动脉粥样硬化(CAS)患者采用司美格鲁肽、津力达颗粒联合治疗后,患者炎性标记物、糖脂代谢、动脉硬化指标的变化情况。方法:按照随机数字表法将138例T2DM合并CAS患者分为对照组和观察组,两组均为69例,所有患者均接受基础治疗,对照组接受司美格鲁肽治疗,观察组接受津力达颗粒联合司美格鲁肽治疗。对比两组临床总有效率、糖脂代谢指标、炎性标记物及动脉硬化指标。结果:观察组的临床总有效率高于对照组(P<0.05)。与对照组相比,观察组治疗后高密度脂蛋白胆固醇(HDL-C)水平更高,空腹血糖(FPG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、餐后2 h血糖(2hPG)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平和中性粒细胞-淋巴细胞比值(NLR)、淋巴细胞-单核细胞比值(LMR)、血小板-淋巴细胞比值(PLR)、颈动脉内膜中层厚度(CIMT)、阻力指数(RI)、颈股脉搏波传导速度(cfPWV)、动脉反射波增强指数(Alx)更低(P<0.05)。结论:T2DM合并CAS患者采用司美格鲁肽、津力达颗粒联合治疗,可进一步提高临床疗效,考虑与改善糖脂代谢、炎性标记物及动脉硬化指标有关。Objective:To observe the changes of inflammatory markers,glucose and lipid metabolism,and atherosclerosis indicators in patients with type 2 diabetes mellitus(T2DM)and carotid atherosclerosis(CAS)treated with smeglutide and Jinlida granules.Methods:138 patients with T2DM combine with CAS were divided into control group and observation group according to the random number table method,the number of cases in both groups was 69.All patients received basic treatment,control group received semeglutide treatment,and observation group received jinlida granules combine with semeglutide treatment.The total clinical effective rate,glycolipid metabolism indexes,inflammatory markers and arteriosclerosis indexes were compared in two groups.Results:The total clinical effective rate in observation group was higher than that in control group(P<0.05).Compared with control group,the level of high density lipoprotein cholesterol(HDL-C)in observation group was higher after treatment,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),2-hour postprandial blood glucose(2hPG),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG)levels and neutrophil-lymphocyte ratio(NLR),lymphocyte-monocyte ratio(LMR),platelet-lymphocyte ratio(PLR),carotid intima-media thickness(CIMT),resistance index(RI),carotid-femoral pulse wave velocity(cfPWV),arterial reflection wave enhancement index(Alx)were lower(P<0.05).Conclusion:Jinlida granules combined with semeglutide in the treatment of patients with T2DM combined with CAS can further improve the clinical efficacy,which is closely relate to the improvement of glycolipid metabolism,inflammatory markers and arteriosclerosis indexes.

关 键 词：津力达颗粒 司美格鲁肽 2型糖尿病 颈动脉粥样硬化 糖脂代谢 炎性标记物 动脉硬化指标 

分 类 号：R587.2[医药卫生—内分泌] R543.5[医药卫生—内科学]