芪冬颐心口服液联合盐酸曲美他嗪片对老年冠心病心绞痛患者心肌损伤指标、免疫功能和氧化应激的影响  

Effects of Qidong Yixin Oral Liquid Combined with Trimetazidine Hydrochloride Tablets on Myocardial Injury Indexes,Immune Function and Oxidative Stress in Elderly Patients with Coronary Heart Disease and Angina Pectoris

作　　者：余研 冯茜 翁友飞 卓龙彩 蔡累 YU Yan;FENG Qian;WENG You-fei;ZHUO Long-cai;CAI Lei(Department of Geriatrics,The 73rd Group Hospital of the Chinese People's Liberation Army(Success Hospital Affiliated to Xiamen University),Xiamen,Fujian,361003,China;Department of Cardiology,The 73rd Group Hospital of the Chinese People's Liberation Army(Success Hospital Affiliated to Xiamen University),Xiamen,Fujian,361003,China)

机构地区：[1]中国人民解放军陆军第七十三集团军医院(厦门大学附属成功医院)老年科,福建厦门361003 [2]中国人民解放军陆军第七十三集团军医院(厦门大学附属成功医院)心内科,福建厦门361003

出　　处：《现代生物医学进展》2024年第20期3990-3992,共3页Progress in Modern Biomedicine

基　　金：福建省卫生计生科研人才培养项目(2018-2-88)。

摘　　要：目的:观察芪冬颐心口服液联合盐酸曲美他嗪片对老年冠心病心绞痛患者心肌损伤指标、免疫功能和氧化应激的影响。方法:按照随机数字表法将我院2020年12月-2022年12月收治的118例冠心病心绞痛患者分为对照组(59例,盐酸曲美他嗪片治疗)和研究组(59例,芪冬颐心口服液联合盐酸曲美他嗪片治疗)。对比两组心功能指标、心肌损伤指标、免疫功能指标和氧化应激指标。结果:研究组治疗4周后丙二醛(MDA)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白(cTnI)、脑钠肽(BNP)、CD8^(+)更低,左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)更小,超氧化物歧化酶(SOD)、左心室射血分数(LVEF)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)更高(P<0.05)。结论:老年冠心病心绞痛患者经芪冬颐心口服液与盐酸曲美他嗪片联合治疗,可有效改善心功能、心肌损伤、免疫功能和氧化应激指标。Objective:To observe the effects of qidong yixin oral liquid combined with trimetazidine hydrochloride tablets on myocardial injury indexes,immune function and oxidative stress in elderly patients with coronary heart disease and angina pectoris.Methods:118 patients with angina pectoris of coronary heart disease admitted to our hospital from December 2020 to December 2022were divided into control group(59 cases,treated with trimetazidine hydrochloride tablets)and study group(59 cases,treated with qidong yixin oral liquid combined with trimetazidine hydrochloride tablets)according to the random number table method.The cardiac function indexes,myocardial injury indexes,immune function indexes and oxidative stress indexes in two groups were compared.Results:The malondialdehyde(MDA),creatine kinase isoenzyme(CK-MB),cardiac troponin(cTnI),brain natriuretic peptide(BNP),CD8^(+)were lower in study group 4 weeks after treatment,the left ventricular end-diastolic diameter(LVEDd)and left ventricular end-systolic diameter(LVESd)were smaller,and the superoxide dismutase(SOD),left ventricular ejection fraction(LVEF),CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were higher(P<0.05).Conclusion:Qidong Yixin oral liquid combined with trimetazidine hydrochloride tablets can effectively improve cardiac function,myocardial injury,immune function and oxidative stress indexes in elderly patients with coronary heart disease and angina pectoris.

关 键 词：芪冬颐心口服液 盐酸曲美他嗪片 老年 冠心病心绞痛 心肌损伤 免疫功能 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]