1,25-二羟维生素D_(3)在自身免疫性疾病中的研究进展  

Research progress of 1,25-dihydroxyvitamin D_(3)in autoimmune diseases

作　　者：张玉 ZHANG Yu(Department of Clinical Laboratory,Tianjin Beichen District Maternal and Child Health and Family Planning Service Center,Tianjin 300400,China)

机构地区：[1]天津市北辰区妇幼保健计划生育服务中心检验科,天津300400

出　　处：《中国城乡企业卫生》2024年第10期23-25,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：1,25-二羟维生素D_(3)是人体内维生素D_(3)的活性形式,在人体机能运行中,主要参与钙和磷等物质的代谢,对人体的健康有着重要的作用和影响。临床研究显示,1,25-二羟维生素D_(3)在人体免疫调节的过程中发挥着重要的作用,主要和自身免疫性疾病有关,补充1,25-二羟维生素D_(3)可以治疗和预防部分自身免疫性疾病。维生素D_(3)是维生素的一种,具有可溶性,人体获取维生素的途径通常有两种,分别是外源性和内源性。通过外源性获取维生素的比例为11%~21%,通过内源性获取维生素的比例为81%~91%,外源性维生素主要是通过食物的途径获取,而内源性维生素的获取主要是通过阳光照射皮肤之后合成,两者之间有着一定的区别。通过食物和皮肤途径获取的维生素在经过25-羟化酶代谢之后,形成25-羟维生素D_(3),在人体肾脏中进一步通过1α-羟化酶代谢之后,可以形成具有生物活性的1,25-二羟维生素D_(3)。本文对1,25-二羟维生素D_(3)在自身免疫性疾病中的应用研究进展进行综述,以期为自身免疫性疾病的治疗提供帮助。1,25-dihydroxyvitamin D_(3)is the active form of vitamin D_(3)in the human body.It mainly participates in the metabolism of substances such as calcium and phosphorus in the operation of the human body functions,and has an important role and impact on human health.The clinical studies show that 1,25-dihydroxyvitamin D_(3)plays an important role in the process of human immune regulation,mainly related to autoimmune diseases.Supplementing with 1,25-dihydroxyvitamin D_(3)can treat and prevent some autoimmune diseases.Vitamin D_(3)is a type of vitamin that is soluble.There are usually two ways for the human body to obtain vitamins,namely exogenous and endogenous.The proportion of vitamins obtained through exogenous is 11%to 21%,while the proportion of vitamins obtained through endogenous is 81%to 91%.Exogenous vitamins are mainly obtained through the way of food,while endogenous vitamins are mainly synthesized after exposure to sunlight on the skin.There is a certain difference between the two.After 25-hydroxylase metabolism,the vitamin obtained from the way of food and skin can form 25-hydroxylase vitamin D_(3).After further 1α-hydroxylase metabolism in human kidney,1,25-dihydroxyvitamin D_(3)with biological activity can be formed.This article reviews the research progress on the application of 1,25-dihydroxyvitamin D_(3)in autoimmune diseases,in order to provide assistance for the treatment of autoimmune diseases.

关 键 词：1 25-二羟维生素D_(3) 免疫调节 自身免疫性疾病 

分 类 号：R392.12[医药卫生—免疫学]