维生素D调控子宫内膜异位症免疫学发病机制的研究进展  

Research progress on the immunological pathogenesis of endometriosis regulated by vitamin D

作　　者：廖琪 徐芳[2] 冯晓玲[2] 匡洪影[2] 张晴 孙淼[2] Liao Qi;Xu Fang;Feng Xiaoling;Kuang Hongying;Zhang Qing;Sun Miao(Graduate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,Xi'an Hospital of Traditional Chinese Medicine,Xi'an 710021,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科二科,哈尔滨150040 [3]西安市中医医院妇科,西安710021

出　　处：《中华生殖与避孕杂志》2024年第10期1002-1008,共7页Chinese Journal of Reproduction and Contraception

基　　金：中国中西医结合妇产科专项研究基金普正制药专项(FCK-PZ-02);中国中西医结合妇产科专项研究基金(FCK-ZSYTW-02)。

摘　　要：维生素D作为一种重要的免疫调节素,通过与免疫细胞的维生素D受体结合,以影响其表达、增殖和凋亡等,从而发挥免疫调节作用,与慢性炎症性疾病、自身免疫性疾病等相关。近年研究显示,子宫内膜细胞也表达维生素D受体,并且子宫内膜异位症患者相关免疫因子表达水平与维生素D水平具有相关性。故本文就维生素D水平调控子宫内膜异位症免疫学发病机制的研究进展作一综述。As an important immunomodulator,vitamin D is involved in the expression,proliferation and apoptosis of immune cells through binding with the vitamin D receptor of immune cells,so as to play an immunomodulatory role,which is related to chronic inflammatory diseases and autoimmune diseases.Recent studies have found that endometrial cells also express vitamin D receptors,and the expression level of relevant immune factors in endometriosis patients are correlated with vitamin D levels.Therefore,this article will review the research progress on the regulation of vitamin D levels on the immunological pathogenesis of endometriosis.

关 键 词：维生素D 子宫内膜异位症 免疫学发病机制 

分 类 号：R711.71[医药卫生—妇产科学]