尿酸代谢在多囊卵巢综合征患者中的研究现状  

Research status of uric acid metabolism in patients with polycystic ovary syndrome

作　　者：兰婷婷 王静[1] 但敏 刘圆圆 曹明雅 赵志明[1] Lan Tingting;Wang Jing;Dan Min;Liu Yuanyuan;Cao Mingya;Zhao Zhiming(Department of Reproductive Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院生殖科,石家庄050000

出　　处：《中华生殖与避孕杂志》2024年第10期1015-1020,共6页Chinese Journal of Reproduction and Contraception

基　　金：2022年河北省省级科技计划(22377742D);2022年河北医科大学第二医院科学研究基金项目(2HC202203);2023年河北省财政府资助临床医学优秀人才培养项目(ZF2023107)。

摘　　要：近年来随着对尿酸的研究不断深入,发现尿酸代谢异常不仅与肾脏和心血管疾病有关,也与多囊卵巢综合征(polycystic ovary syndrome,PCOS)等生殖系统疾病有着密切的联系。尿酸可通过氧化应激、慢性炎症、干扰关键酶活性等机制在PCOS的发生、发展中发挥重要作用,PCOS以高雄激素血症、胰岛素抵抗、糖脂代谢异常等为主要临床表现,已有研究数据表明高尿酸血症与高雄激素血症、异常的糖脂代谢之间存在相互作用,同时升高的血清尿酸还与PCOS患者更高的妊娠并发症发生率及不良妊娠结局相关。然而,目前关于此方面的综述较少。因此,本综述旨在通过深入探讨尿酸代谢与PCOS主要临床表现之间的相互关系,以及尿酸代谢异常对PCOS不孕患者妊娠结局及并发症的影响,以期为PCOS的临床治疗和管理提供更为全面的科学依据。With the deepening of the research on uric acid,it has been found that abnormal uric acid metabolism is not only related to kidney and cardiovascular diseases,but also closely related to reproductive system diseases such as polycystic ovary syndrome(PCOS).Uric acid can play an important role in the occurrence and development of PCOS through oxidative stress,chronic inflammation and interference with key enzyme activities.PCOS is primarily characterized by hyperandrogenemia,insulin resistance,and dysregulation of glucose and lipid metabolism.Researches have found that there is an interaction between hyperuricemia and hyperandrogenemia,as well as abnormal glucose and lipid metabolism.Additionally,elevated serum uric acid levels are associated with a higher incidence of pregnancy complications and adverse pregnancy outcomes in women with PCOS.However,there are few reviews on this aspect.Therefore,this review aims to provide a more comprehensive scientific basis for the clinical treatment and management of PCOS by deeply exploring the relationship between uric acid metabolism and the main clinical manifestations of PCOS,as well as the impact of abnormal uric acid metabolism on pregnancy outcomes and complications in PCOS patients.

关 键 词：尿酸 多囊卵巢综合征 高雄激素血症 胰岛素抵抗 脂代谢异常 排卵抑制 脂肪组织 降尿酸治疗 饮食 

分 类 号：R711.75[医药卫生—妇产科学]