PCOS患者子宫内膜容受性缺陷研究进展  

Research progress of endometrial receptivity defects in patients with PCOS

作　　者：陈佳媛 倪天翔[1] 颜军昊[1] Chen Jiayuan;Ni Tianxiang;Yan Junhao(Shandong University Institute of Women,Children and Reproductive Health,Shandong University National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong Provincial Clinical Research Center for Reproductive Health,Jinan 250012,China)

机构地区：[1]山东大学妇儿与生殖健康研究院、山东大学国家辅助生殖与优生工程技术研究中心、山东省生殖健康临床医学研究中心,济南250012

出　　处：《中华生殖与避孕杂志》2024年第10期1021-1026,共6页Chinese Journal of Reproduction and Contraception

基　　金：山东省自然科学基金青年项目(ZR2021QH075)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种多发于育龄期女性的生殖内分泌疾病,严重影响了女性的生活质量和生育能力,对身心健康和经济能力都造成打击。目前针对PCOS患者的稀发排卵、内分泌失调等问题已可以通过促排卵药物纠正,但患者的子宫内膜容受性仍处于不良状态,依然存在无法受孕的情况。PCOS患者子宫内膜容受性缺陷与代谢、免疫、激素及其受体异常表达等密切相关,不过具体的病理机制以及病因尚未完全阐明。本文主要讨论了PCOS患者子宫内膜容受性缺陷的因素,并围绕遗传及表观遗传学异常、代谢异常、免疫紊乱三个角度展开,试图为PCOS患者的治疗方案以及新的药物靶标提供一些线索。Polycystic ovary syndrome(PCOS)is a reproductive endocrine disorder that is more common in women of childbearing age,which seriously affects women's quality of life and fertility,taking a toll on both physical and mental health as well as economic capacity.At present,the problems of thin ovulation and endocrine disorders in PCOS patients can be corrected by fertility drugs,but the endometrial receptivity of the patients is still in a poor state,and there is still a situation of inability to conceive.Current studies have shown that endometrial receptivity defects in PCOS patients are closely related to abnormal expression of metabolism,immunity,hormones and their receptors,etc.However,the specific pathological mechanism and etiology have not been fully clarified.This paper mainly discusses the factors of endometrial receptivity defects in patients with PCOS,and focuses on three aspects:genetic and epigenetic abnormalities,metabolic abnormalities,and immune disorders,trying to provide some clues for future treatment options and new drug targets for PCOS patients.

关 键 词：多囊卵巢综合征 子宫内膜容受性 代谢 全基因组关联研究 

分 类 号：R711.75[医药卫生—妇产科学]