卵巢组织冻存和移植在女性儿童肿瘤患者生育力保存中的研究进展  

Progress of ovarian tissue cryopreservation and transplantation in the fertility preservation of female childhood cancer patients

作　　者：杨金泽 巩建飞 张萌萌 颜景灏 杨深 宋雪凌 朱志云 王海燕[1] 王焕民[3] 严杰 Yang Jinze;Gong Jianfei;Zhang Mengmeng;Yan Jinghao;Yang Shen;Song Xueling;Zhu Zhiyun;Wang Haiyan;Wang Huanmin;Yan Jie(State Key Laboratory of Female Fertility Promotion,National Clinical Research Center for Obstetrics and Gynecology,Key Laboratory of Assisted Reproduction(Peking University,Ministry of Education),Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China;Department of Gynecology,Beijing Nuclear Industry Hospital,Beijing 100045,China;Department of Surgical Oncology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]女性生育力促进全国重点实验室、国家妇产疾病临床医学研究中心、辅助生殖教育部重点实验室(北京大学)、北京大学第三医院妇产科生殖医学中心,北京100191 [2]北京核工业医院妇科,北京100045 [3]国家儿童医学中心、首都医科大学附属北京儿童医院肿瘤外科,北京100045

出　　处：《中华生殖与避孕杂志》2024年第10期1036-1041,共6页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金重大项目(T2293764);国家重点研发计划(2022YFC2703000)。

摘　　要：随着肿瘤治疗技术不断发展,儿童恶性肿瘤治愈率不断提高。幸存患儿的卵巢发育与功能常受到放化疗的不可逆损害,导致医源性卵巢早衰甚至不孕,因此开展针对肿瘤患儿的生育力保存具有重要意义。国际国内指南共识指出女性儿童应首先考虑卵巢组织冻存和移植,但这一技术在儿童中的应用尚不成熟,儿童卵巢与成人存在结构和功能上的巨大差异,导致针对成人的生育力保存策略并不完全适用于儿童。因此,本文对儿童卵巢的结构和功能特点对于卵巢组织冻存和移植的影响、放化疗对卵巢组织的损伤机制、卵巢组织冻存和移植在临床应用的现状进行分析和梳理,展望了女性儿童生育力保存技术的研究前景。With the continuous development of cancer treatment technology,the cure rate for tumors in children is increasing.However,the irreversible damage to ovarian development and function by chemotherapy and radiation in surviving children often leads to iatrogenic premature ovarian failure and even infertility.Therefore,it is of great significance to develop fertility preservation techniques for children with tumors.International and domestic guidelines indicate that ovarian tissue cryopreservation and transplantation should be considered first for female children.However,the application of this technique in children is not yet mature.Current research suggests that there are significant structural and functional differences between children's ovaries and adults',and fertility preservation strategies for adults are not fully applicable to children.Therefore,this paper analyzes and reviews the structure and function of children's ovaries,the mechanism of damage to ovarian tissues by chemotherapy and radiation,and the current research and application status of fertility preservation techniques for female children.It also looks forward to the development direction of fertility preservation techniques for female children.

关 键 词：生育力保存 卵巢组织冻存 卵巢组织移植 肿瘤 儿童 

分 类 号：R714.8[医药卫生—妇产科学] R730[医药卫生—临床医学]