ncRNA调控颗粒细胞程序性死亡影响多囊卵巢综合征的研究进展  

Advances in ncRNA regulation of programmed cell death affecting polycystic ovary syndrome

作　　者：任普佳 李德邦 代特日格勒 陈秀娟[1] 杜琛[1] Ren Pujia;Li Debang;Dai Terigele;Chen Xiujuan;Du Chen(Center for Reproductive Medicine,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院生殖医学中心,呼和浩特010050

出　　处：《中华生殖与避孕杂志》2024年第10期1085-1091,共7页Chinese Journal of Reproduction and Contraception

基　　金：内蒙古自治区“十四五”重点研发及成果转化项目(2022YFSH0067);内蒙古医科大学附属医院青年骨干项目(2023NYFYGG002);内蒙古医科大学笃学人才项目(ZY20243116);内蒙古医科大学面上项目(YKD2022MS017);内蒙古教育厅高校科研项目(NJZY19104)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性最常见的生殖内分泌紊乱性疾病之一,病理机制尚未阐明。诸多研究证实细胞程序性死亡(programmed cell death,PCD)可影响PCOS的发生发展,调控PCD可能成为防治PCOS的关键。最近研究揭示了许多与表观遗传相关的非编码RNA(non-coding RNA,ncRNA),包括微小RNA、长链非编码RNA及环状RNA等,它们虽不直接作为遗传信息载体,但能通过调节相关蛋白和基因的表达来启动各种细胞的反应机制,如细胞凋亡、自噬、铁死亡、坏死性凋亡和焦亡等,从而影响颗粒细胞发育,干扰内分泌稳态,参与PCOS的病理过程并影响其预后。本文对ncRNA通过调控颗粒细胞的PCD影响PCOS的致病机理展开讨论,以期为PCOS的治疗提供新的思路。Polycystic ovary syndrome(PCOS)is one of the most common reproductive endocrine disorders in women of reproductive age,and its pathogenesis is not yet fully understood.Many studies have confirmed that programmed cell death(PCD)can affect the occurrence and development of PCOS,and regulating PCD may be the key to prevent and treat PCOS.Recent researches have revealed many non-coding RNA(ncRNA)related to epigenetics,including microRNA,long ncRNA,and circular RNA.Although these ncRNA do not directly serve as carriers of genetic information,they can activate various cellular response mechanisms by regulating the expression of related proteins and genes,such as apoptosis,autophagy,ferroptosis,necroptosis,and pyroptosis,thereby affecting granulosa cell development,disrupting endocrine homeostasis,participating in the pathological process of PCOS,and influencing its prognosis.This paper discusses the pathogenesis of PCOS through the regulation of PCD by ncRNA,aiming to provide new insights for the treatment of PCOS.

关 键 词：多囊卵巢综合征 细胞程序性死亡 颗粒细胞 

分 类 号：R711.75[医药卫生—妇产科学]