黏附分子在胚胎着床中的作用机制研究进展  

Advances in the mechanism of adhesion molecules during embryo implantation

作　　者：李文竹 邓志敏 魏伊秋 杨冬咏 蔡松辰 杨玲桃 尹太郎[1] 刁梁辉 Li Wenzhu;Deng Zhimin;Wei Yiqiu;Yang Dongyong;Cai Songchen;Yang Lingtao;Yin Tailang;Diao Lianghui(Reproductive Medical Center,Renmin Hospital of Wuhan University,Wuhan 430060,China;Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation,Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics,Shenzhen Zhongshan Obstetrics&Gynecology Hospital(formerly Shenzhen Zhongshan Urology Hospital),Shenzhen 518045,China)

机构地区：[1]武汉大学人民医院生殖医学中心,武汉430060 [2]深圳中山妇产医院(原深圳中山泌尿外科医院)生殖医学临床研究中心、深圳中山生殖与遗传研究所、广东省围着床期生殖免疫工程技术研究中心,深圳518045

出　　处：《中华生殖与避孕杂志》2024年第10期1098-1105,共8页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82371684,82271672)。

摘　　要：胚胎着床是一个复杂且精密的动态过程,涉及子宫内膜容受性的建立、胚胎定位、黏附和侵袭。黏附分子作为细胞间或细胞与细胞外基质的重要通信调节器,在维持子宫内膜容受性、调节胚胎定位、黏附和侵袭方面起着关键作用。然而,对于母体和胚胎来源的黏附分子如何有序地调控围着床期的关键事件仍然有待深入研究。本文结合最新研究进展,根据胚胎着床的几个关键节点,总结了不同类型的黏附分子在母-胎界面的作用及其可能的调控机制,特别介绍了在着床过程中黏附分子调节蜕膜免疫细胞与其他细胞的相互作用,为黏附分子功能失调介导的着床失败提供新视角和洞见。The process of embryo implantation is a multifaceted and intricate dynamic event that includes the development of endometrial receptivity,embryo localization,adhesion,and invasion.Adhesion molecules,acting as crucial mediators of communication between cells or between cells and the extracellular matrix,are essential for the maintenance of endometrial receptivity and the regulation of embryo localization,adhesion,and invasion.However,the mechanisms by which adhesion molecules of maternal and embryo are organized to regulate key events in the peri-implantation period have yet to be fully explored.Based on recent research findings,this review provides a summary of the functions of different adhesion molecules at the maternal-fetal interface and their potential regulatory mechanisms according to the key progress of embryo implantation.In particular,we discussed the interactions between decidual immune cells and other cells mediated by adhesion molecules during the invasion process,which will provide novel perspectives into the role of adhesion molecule dysfunction in contributing to implantation failure.

关 键 词：胚胎着床 黏附分子 子宫内膜容受性 胚胎侵袭 蜕膜免疫细胞 

分 类 号：R714.8[医药卫生—妇产科学]