T2DM患者血游离脂肪酸、ω-3多不饱和脂肪酸、饱和脂肪酸变化及与糖尿病肾病发生的相关性  

Changes in Serum Free Fatty Acids,Omega-3 Polyunsaturated Fatty Acid,Saturated Fatty Acid in Patients with Diabetes Mellitus Type 2 and Their Correlation with Diabetic Nephropathy

作　　者：陈青云 廖继成[1] 李晨 CHEN Qingyun;LIAO Jicheng;LI Chen(Department of Laboratory Medicine,Chengdu Sirth People's Hospital Chengdu Sichuan 610066,China)

机构地区：[1]成都市第六人民医院检验科,四川成都610066 [2]四川省肿瘤医院实验研究部

出　　处：《联勤军事医学》2024年第9期753-757,共5页Military Medicine of Joint Logistics

基　　金：成都市医学科研课题(2022520)。

摘　　要：目的探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血游离脂肪酸(free fatty acid,FFA)、ω-3多不饱和脂肪酸(omega-3 polyunsaturated fatty acid,ω-3PUFA)、饱和脂肪酸水平变化及与糖尿病肾病(diabetic kidney disease,DKD)发生的相关性。方法随机选取2023-01/2023-12月作者医院收治的84例DKD患者纳入DKD组,选取同期60例单纯T2DM患者纳入T2DM组,另选取60例健康体检者纳入对照组。比较3组受试者FFA、ω-3PUFA及饱和脂肪酸水平,检测并比较3组受试者肾功能血尿酸(uric acid,UA)、血肌酐(creatinine,Cr)、肾小球滤过率(glomerular filtration rate,eGFR)和尿蛋白水平。采用Pearson法分析DKD患者血FFA、ω-3PUFA及饱和脂肪酸水平与肾功能UA、Cr、eGFR和尿蛋白水平的相关性。根据eGFR水平将DKD患者分为预后良好组(n=49)和预后不良组(n=35),比较两组患者血FFA、ω-3PUFA、饱和脂肪酸水平。结果与对照组比较,DKD组、T2DM组患者FFA、饱和脂肪酸、UA、Cr、尿蛋白水平明显升高,ω-3PUFA、eGFR水平明显降低(P均<0.05);与T2DM组比较,DKD组患者FFA、饱和脂肪酸、UA、Cr、尿蛋白水平明显升高,ω-3PUFA、eGFR水平明显降低(P均<0.05)。Pearson相关性分析显示,FFA、饱和脂肪酸水平与UA、Cr、尿蛋白水平呈正相关关系,与eGFR水平呈负相关关系(P<0.05);而ω-3PUFA水平与UA、Cr、尿蛋白水平呈负相关关系,与eGFR水平呈正相关关系(P<0.05)。预后不良组DKD患者FFA、饱和脂肪酸水平高于预后良好组,而ω-3PUFA水平低于预后良好组(P均<0.05)。结论T2DM患者血FFA、饱和脂肪酸水平升高,且二者水平与DKD发生正相关,ω-3PUFA水平降低,且其水平与DKD发生负相关,并且在一定程度上可反映DKD预后情况。Objective To explore the changes in serum free fatty acid(FFA),omega-3 polyunsaturated fatty acid(ω-3PUFA),saturated fatty acid in the serum of patients with diabetes mellitus type 2(T2DM)and their correlation with the occurrence of diabetic kidney disease(DKD).Methods Eighty-four patients with DKD in author′s hospital from January 2023 to December 2023 were randomly selected and included into the DKD group,60 patients with simple T2DM were enrolled in the T2DM group,and another 60 healthy subjects undergoing physical examination were selected as the control group.The levels of FFA,ω-3PUFA,and saturated fatty acid were compared among the 3 groups,renal function indicators,including serum uric acid(UA),serum creatinine(Cr),glomerular filtration rate(eGFR)and urine protein levels were also measured and compared among the 3 groups.Pearson correlation analysis was employed to examine the relationship between FFA,ω-3PUFA,and saturated fatty acid levels and renal function indicators,such as UA,Cr,eGFR,and urine protein concentrations in DKD patients.According to the eGFR level,patients with DKD were divided into the good prognosis group(n=49)and the poor prognosis group(n=35),the levels of serum FFA,ω-3PUFA,saturated fatty acid were compared between the two groups.Results Compared with the control group,patients in the DKD group and T2DM group had significantly higher levels of FFA,saturated fatty acids,UA,Cr,and urinary protein,whileω-3 PUFA and eGFR levels were significantly lower(all P<0.05);compared with the T2DM group,patients in the DKD group had significantly higher levels of FFA,saturated fatty acids,UA,Cr,and urinary protein,whileω-3 PUFA and eGFR levels were significantly lower(all P<0.05).Pearson correlation analysis showed that FFA and saturated fatty acid levels were positively correlated with UA,Cr,and urinary protein levels,and negatively correlated with eGFR level(P<0.05);conversely,ω-3 PUFA levels were negatively correlated with UA,Cr,and urinary protein levels,and positively correlated with e

关 键 词：2型糖尿病 糖尿病肾病 血游离脂肪酸 Ω-3多不饱和脂肪酸 饱和脂肪酸水平 肾功能 相关性 

分 类 号：R587.1[医药卫生—内分泌] R587.2[医药卫生—内科学]