衰弱对高龄患者肺部感染的影响  

The effect of frailty on pulmonary infection in elderly patients

作　　者：夏魁 孙伟[1] 陆民 周磊[1] 李洁 李淑芹 XIA Kui;SUN Wei;LU Min;ZHOU Lei;LI Jie;LI Shuqin(Department of Respiratory and Critical Care Medicine,Huaibei People′s Hospital,Hefei 235000,China)

机构地区：[1]淮北市人民医院呼吸与危重症医学科,淮北235000

出　　处：《中国临床保健杂志》2024年第5期639-642,共4页Chinese Journal of Clinical Healthcare

基　　金：安徽省高等学校科学研究项目重点项目(2023AH051934)。

摘　　要：目的探讨衰弱对高龄肺部感染患者抗感染治疗时间及再感染概率的影响。方法纳入2021年1月至2022年12月在淮北市人民医院住院的135例高龄(≥80岁)肺部感染患者,根据FRAIL评分分为衰弱组(73例)及非衰弱组(62例)。收集所有患者年龄、性别等人口学资料,以及基础疾病、营养情况(MNA)、肺部感染治疗时间、90 d及180 d内再感染率等相关临床资料。结果衰弱组抗感染治疗时间[(12.2±2.4)d]长于非衰弱组[(9.8±1.7)d],差异有统计学意义(P<0.05)。衰弱组抗感染治疗结束后90 d及180 d内再感染率分别为38.4%、58.9%,高于非衰弱组22.6%、38.7%,差异均有统计学意义(均P<0.05)。结论衰弱会使高龄肺部感染患者抗感染治疗时间延长,近中期再感染概率增加。这可能与合并衰弱者慢病多、营养状况差有关,应及早评估、发现衰弱,加强管理及干预。Objective To explore the effect of frailty on anti-infection treatment time and reinfection rate in elderly patients with pneumonia.Methods One hundred and thirty-five elderly patients(≥80 years old)with pneumonia in Huaibei People′s Hospital from January 2021 to December 2022 were enrolled,and they were divided into frail group(n=73)and non-frail group(n=62)according to frail score.The demographic data such as age and sex,as well as clinical data such as concomitant diseases,nutritional status(MNA),pneumonia treatment time,and reinfection rates within 90 days and 180 days were collected.Results The anti-infection treatment time of the frail group[(12.2±2.4)d]was longer than the non-frail group[(9.8±1.7)d],and the difference was statistically significant(P<0.05).The reinfection rates in the frail group were 38.4%and 58.9%at 90 d and 180 d after treatment respectively,which were significantly higher than those in the non-frail group,the differences were statistically significant(P<0.05).Conclusions Frailty will prolong the anti-infection treatment time of elderly patients with pneumonia,and increase the probability of reinfection.It may be related to chronic disease and poor nutritional status in patients with frailty.Early assessment and detection of frailty should be carried out,and management and intervention should be strengthened.

关 键 词：肺炎 衰弱 再感染 药物相关性副作用和不良反应 老年人 80以上 

分 类 号：R563.1[医药卫生—呼吸系统]