氘代药物唑吡坦-d_(7)的一种合成方法  

A Synthetic Method of Deuterated Drug Zolpidem-d_(7)

作　　者：杜鸿雁 陈相全 任昕昕 宋歌 王振华 袁伟成 DU Hongyan;CHEN Xiangquan;REN Xinxin;SONG Ge;WANG Zhenhua;YUAN Weicheng(Institute of Forensic Science of China,Beijing 100038,China;Innovation Research Center of Chiral Drugs,Institute for Advanced Study,Chengdu University,Chengdu 610106,China)

机构地区：[1]公安部鉴定中心,北京100038 [2]成都大学高等研究院手性药物创新研究中心,四川成都610106

出　　处：《合成化学》2024年第11期938-943,共6页Chinese Journal of Synthetic Chemistry

基　　金：北京市现场物证检验工程技术研究中心开放课题项目(2022CSEEKFKT04);四川省自然科学基金资助项目(2024NSFSC0281)。

摘　　要：唑吡坦是一种国家二类精神药物,具有潜在的滥用风险。为了预防可能出现的安全事件,对涉及该药物的样本进行快速准确的检测至关重要。唑吡坦-d_(7)作为唑吡坦残留检测所需的重要内标化合物,其在分析检测中的重要性不言而喻。基于此背景,本文报道了一种合成唑吡坦-d_(7)的方法。以甲苯-d_(8)为起始原料,经过傅-克酰基化、环化反应、缩合反应、酯水解、黄鸣龙还原和酰胺化反应合成了唑吡坦-d_(7),该化合物结构经^(1)H NMR、^(13)C NMR和IR得到了进一步的确证,经HPLC分析纯度达到99.49%。Zolpidem is a Class II controlled substance in China with potential abuse risks.In order to prevent possible safety incidents,it is critical to perform rapid and accurate testing of samples containing this drug.Zolpidem-d_(7)is an essential internal standard compound for detecting zolpidem residues and is undeniably significant in analytical testing.In this context,this paper presents a method for synthesizing zolpidem-d_(7).With toluene-d_(8)as the starting material,zolpidem-d_(7)was synthesized via the reaction of Friedel-Crafts acylation,cyclization,condensation,ester hydrolysis,Huang-Minlon reduction,and amidation.The structure was confirmed by^(1)H NMR,^(13)C NMR,and IR,and its purity was determined to be 99.49%by HPLC analysis.

关 键 词：甲苯-d_(8) 唑吡坦-d_(7) 傅-克酰基化 黄鸣龙还原 合成 

分 类 号：O621.3[理学—有机化学]