康复新液加胆石利通片联合莫沙必利治疗胆囊切除术后胆汁反流性胃炎的临床疗效研究  

Study of clinical efficacy of Kangfuxin Liquid plus Danshilitong Tablets combined with Mosapride in the treatment of bile reflux gastritis after cholecystectomy

作　　者：邢时龙 孙亭立[1] 胡莉红[1] 徐林龙 XING Shilong;SUN Tingli;HU Lihong;XU Linlong(Department of Hepatobiliary and Pancreatic Surgery,Jiu Jiang NO.1 People's Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院肝胆胰外科,江西九江332000

出　　处：《中国当代医药》2024年第32期34-38,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0885)。

摘　　要：目的探讨康复新液加胆石利通片联合莫沙必利治疗胆囊切除术后胆汁反流性胃炎(BRG)的临床疗效。方法选择2022年10月至2023年10月在九江市第一人民医院行胆囊切除术治疗且术后出现BRG的60例患者作为研究对象,根据随机数字表法分为试验组(n=30)和对照组(n=30)。对照组患者接受胆石利通片联合莫沙必利治疗,试验组患者在对照组基础上加用康复新液治疗,两组均连续治疗4周。比较两组的临床疗效、临床症状积分、24 h内胆汁反流情况、实验室指标。结果试验组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的临床症状积分低于本组治疗前,且试验组的临床症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的24 h内最长反流时间均短于本组治疗前,反流次数与反流时间>5 min次数均少于本组治疗前,且试验组的24 h内最长反流时间短于对照组,反流次数与反流时间>5 min次数均少于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均低于本组治疗前,胃泌素17(G-17)、降钙素基因相关肽(CGRP)水平均高于本组治疗前,且试验组的IL-6、TNF-α水平均低于对照组,G-17、CGRP水平均高于对照组,差异有统计学意义(P<0.05)。结论胆囊切除术后BRG使用康复新液、莫沙必利、胆石利通片联合治疗可有效调节炎症因子、胃肠激素水平,更好地改善患者胆汁反流情况,减轻临床症状,促进疾病恢复。Objective To investigate clinical efficacy of Kangfuxin Liquid plus Danshilitong Tablets combined with Mosapride in the treatment of bile reflux gastritis(BRG)after cholecystectomy.Methods A total of 60 patients with BRG after cholecystectomy in Jiu Jiang NO.1 People's Hospital from October 2022 to October 2023 were selected as research objects,and they were divided into the experimental group(n=30)and the control group(n=30)according to the random number table method.The patients in the control group were treated with Danshilitong Tablets combined with Mosapride,and the patients in the experimental group were treated with Kangfuxin Liquid on the basis of the control group.Both groups were treated for 4 weeks.The clinical efficacy,clinical symptom score,bile reflux within 24 hours,and laboratory indexes were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the clinical symptom scores of the two groups were lower than those before treatment,and the clinical symptom scores of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the longest reflux time within 24 hours of the two groups were shorter than those before treatment,the number of reflux times and the number of reflux time>5 min were less than those before treatment,and the longest reflux time within 24 hours of the experimental group was shorter than that of the control group,the number of reflux times and the number of reflux time>5 min were less than those of the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were lower than those before treatment,and the levels of gastrin-17(G-17)and calcitonin gene related peptide(CGRP)were higher than those before treatment,and the levels of IL-6 and TNF-

关 键 词：胆汁反流性胃炎 康复新液 胆石利通片 莫沙必利 胆囊切除术 

分 类 号：R657.4[医药卫生—外科学] R573.3[医药卫生—临床医学]