俯卧位经鼻间歇正压通气治疗极低出生体重儿呼吸窘迫综合征的临床效果  

Clinical efficacy of prone position nasal intermittent positive pressure ventilation in the treatment of respiratory distress syndrome in very low birth weight infants

作　　者：黄丽荷 黄美亲 陈彩连 蔡启茵 赵永健[1] 梁婉珊 金敏芳 HUANG Lihe;HUANG Meiqin;CHEN Cailian;CAI Qiyin;ZHAO Yongjian;LIANG Wanshan;JIN Minfang(Department of Neonatology,Jiangmen Maternity and Child Health Care Hospital,Guangdong Province,Jiangmen529000,China)

机构地区：[1]广东省江门市妇幼保健院新生儿科,广东江门529000

出　　处：《中国当代医药》2024年第32期78-81,共4页China Modern Medicine

摘　　要：目的探讨俯卧位经鼻间歇正压通气(NIPPV)治疗极低出生体重儿呼吸窘迫综合征的效果。方法选取2023年1月至2024年1月江门市妇幼保健院新生儿科收治的伴有呼吸窘迫综合征的极低出生体重儿为研究对象,按随机数字表法分为观察组与对照组,每组49例。两组均接受NIPPV治疗,每天保持12 h,观察组采用俯卧位通气,对照组采用仰卧位通气。比较两组治疗前后的氧合情况、临床指标及并发症。结果治疗后4、12、24 h,观察组的动脉氧分压、氧合指数高于对照组,动脉二氧化碳分压低于对照组,差异有统计学意义(P<0.05)。治疗后4、12、24 h,观察组的呼吸频率低于对照组,差异有统计学意义(P<0.05)。观察组NIPPV使用时间和住院时间短于对照组,差异有统计学意义(P<0.05)。观察组的呼吸暂停、胃潴留发生率低于对照组,差异有统计学意义(P<0.05);两组的鼻黏膜糜烂发生率比较,差异无统计学意义(P>0.05)。结论俯卧位经鼻间歇正压通气治疗极低出生体重儿呼吸窘迫综合征,能提高氧合,缩短NIPPV使用时间及住院时间,减少并发症发生率。Objective To investigate the effect of nasal intermittent positive pressure ventilation(NIPPV)in the treatment of respiratory distress syndrome in very low birth weight infants.Methods Very low birth weight infants with respiratory distress syndrome admitted to the Department of Neonatology,Jiangmen Maternity and Child Health Care Hospital from January 2023 to January 2024 were selected as the study objects,and were divided into observation group and control group according to random number table method,with 49 cases in each group.Both groups were treated with NIPPV for 12 h a day.The observation group was ventilated in prone position and the control group was ventilated in supine position.The oxygenation,clinical indexes and complications before and after treatment were compared between the two groups.Results At 4,12 and 24 h after treatment,the arterial oxygen partial pressure and oxygenation index in the observation group were higher than those in the control group,and the arterial carbon dioxide fraction was lower than that in the control group,with statistical significances(P<0.05).At 4,12 and 24 h after treatment,the respiratory rate of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).The NIPPV use time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of apnea and gastric retention in observation group was lower than that in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of nasal erosion between the two groups(P>0.05).Conclusion Nasal intermittent positive pressure ventilation in prone position for the treatment of respiratory distress syndrome in very low birth weight infants can improve oxygenation,shorten the duration of NIPPV use and hospitalization,and reduce the incidence of complications.

关 键 词：俯卧位通气 经鼻间歇正压通气 呼吸窘迫综合征 极低出生体重儿 

分 类 号：R722[医药卫生—儿科]