慢性光化性皮炎发病机制研究进展  

Progress in the pathogenesis of chronic actinic dermatitis

作　　者：张梅 农祥[2] ZHANG Mei;NONG Xiang(Department of Dermatology,First People's Hospital of Liangshan Prefecture,Sichuan Province,Xichang 615000;Department of Dermatology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan)

机构地区：[1]四川省凉山州第一人民医院皮肤科,四川西昌615000 [2]昆明医科大学第一附属医院皮肤科,云南昆明650032

出　　处：《皮肤病与性病》2024年第5期299-301,305,共4页Dermatology and Venereology

摘　　要：慢性光化性皮炎发病机制复杂,目前公认的发病机制主要是曝光部位的皮肤于紫外线或可见光照射后出现迟发性超敏反应、氧化应激、细胞凋亡异常、屏障受损。此外,感染、特应性体质、性激素水平紊乱也扮演了重要的角色。本文对最新的慢性光化性皮炎发病机制的研究进展作一综述,为后续的药物研究提供参考。The pathogenesis of chronic actinic dermatitis is complex.The currently recognized mechanism is mainly delayed hypersensitivity reaction,oxidative stress,abnormal apoptosis,and barrier damage in the skin at the exposed site after ultraviolet or visible light irradiation..In addition,infections,atopic constitutions,and disorders of sex hormone also play important roles.This article reviews the latest research progress on the pathogenesis of chronic actinic dermatitis to provide reference for subsequent drug research.

关 键 词：慢性光化性皮炎 机制 转归 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]