TCF7L2基因rs7903146、rs290487多态性与中国人群GDM易感性的meta分析  

Meta-analysis of the correlation of the transcription factor 7-like2 gene rs7903146 and rs290487 polymorphisms of pregnant women and their susceptibility of gestational diabetes mellitus in Chinese population

作　　者：周青 刘帅妹 张瑞金 李孟兰 封婕 黄丽丽 吴玉璘 林宁 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;LI Menglan;FENG Jie;HUANG Lili;WU Yulin;LIN Ning(Jiangsu Health Development Research Center,NHC Key Laboratory of Contraceptives Vigilance and Fertility Surveillance,Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省卫生健康发展研究中心,国家卫生健康委避孕药具警戒与生育力监测重点实验室,江苏省生育力保护与卫生技术评估重点实验室,南京210036

出　　处：《中国计划生育学杂志》2024年第11期2476-2482,共7页Chinese Journal of Family Planning

基　　金：江苏省卫生健康发展研究中心自主科研项目(JSHD2021066);江苏省妇幼健康科研项目“基于血清胎盘来源外泌体miRNAs的妊娠期糖尿病预警模型”(F202040);江苏省妇幼健康科研项目“孕期联合筛查预测早发型子痫前期的临床研究”(F202050);江苏省科教能力提升工程(ZDXYS202210)。

摘　　要：目的:评价转录因子7-类似物2(TCF7L2)基因rs7903146、rs290487多态性与中国人群妊娠期糖尿病(GDM)易感性。方法:检索中国知网、万方、PubMed、Web of science等中英文数据库中有关TCF7L2基因rs7903146、rs290487多态性与中国人群GDM相关性病例对照研究,检索日期截止至2024年6月,采用Stata11.0软件,计算OR和95%CI,评估分析TCF7L2基因多态性与中国人群GDM之间的关系。结果:共纳入10项研究,病例组2581例,健康对照组2738例。meta分析结果显示rs7903146位点多态性与中国人群GDM发病风险存在明显正相关性(TT比CC:OR=5.00,95%CI 2.70-9.28,P_(heterogeneity),Ph=0.946;TT比CC+TC:OR=4.63,95%CI 2.57-8.35,Ph=0.910);rs290487位点多态性与中国人群GDM发病风险存在负相关性(TT比CC+TC:OR=0.86,95%CI 0.76-0.97,Ph=0.157)。结论:TCF7L2基因rs7903146位点多态性可能与中国人群GDM易感性存在正相关性;而rs290487位点多态性可能与中国人群GDM易感性存在负相关性。Objective:To evaluate the correlation of the transcription factor 7-like2(TCF7L2)gene rs7903146 and rs290487 polymorphisms of pregnant women and their susceptibility of gestational diabetes mellitus(GDM)in Chinese population.Methods:By searching Chinese and English databases,such as CNKI,Wanfang,Pubmed and Web of science,the case-control studies about the correlation between TCF7L2 gene rs7903146 and rs290487 polymorphisms of the pregnant women and their GDM susceptibility in Chinese population were collected.The relevant studies were searched in these databases up to June 2024.The odds ratio(OR)value and its 95% confidence interval(CI)were calculated to evaluate the correlation between the TCF7L2 gene polymorphisms of the pregnant women and their GDM susceptibility by Stata11.0 software.Results:A total of 10studies were included,including 2581women in the cases group and 2738 health women in the control group.The results of meta-analysis showed that the rs7903146 locus polymorphism of the women was positively correlated with the risk of their GDM occurrence(TT vs.CC:OR=5.00,95%CI 2.70-9.28,Ph=0.946;TT vs.CC+TC:OR=4.63,95%CI 2.57-8.35,Ph=0.910).The rs290487 locus polymorphism of the women was negatively associated with the risk of their GDM occurrence(TT vs.CC+TC:OR=0.86,95%CI 0.76-0.97,Ph=0.157).Conclusion:The rs7903146 locus polymorphism of the TCF7L2 gene of the pregnant women in China may be positively correlated with their GDM susceptibility,but the rs290487 locus polymorphism of the TCF7L2 gene of the women may be negatively associated with their GDM susceptibility.

关 键 词：妊娠期糖尿病 易感性 基因多态性 转录因子7-类似物2 

分 类 号：R714.256[医药卫生—妇产科学]