孕前BMI和孕早期血脂水平与新生儿早产关系  

Correlation between the pre-pregnancy body mass index and the serum lipid level of pregnant women during the first trimester of pregnancy and their premature delivery

作　　者：牟莎莎 高玉盛 张海艳 张建军 MOU Shasha;GAO Yusheng;ZHANG Haiyan;ZHANG Jianjun(Shandong Second Medical University,Weifang,Shandong Province,261053;Qingdao Jiaozhou Central Hospital;The Affiliated Hospital of Shandong Second Medical University,Weifang Key Laboratory of Postpartum Pelvic Floor Myoelectric Rehabilitation)

机构地区：[1]山东第二医科大学,潍坊261053 [2]青岛市胶州中心医院 [3]山东第二医科大学附属医院,潍坊市产后盆底肌电康复重点实验室

出　　处：《中国计划生育学杂志》2024年第11期2574-2579,共6页Chinese Journal of Family Planning

基　　金：潍坊市科技局科研基金(2022YX027);青岛市医疗卫生重点学科建设项目。

摘　　要：目的:分析孕前BMI和孕早期血脂水平对新生儿早产发生的可能影响。方法:前瞻性队列研究,收集2022年1-12月于本院产科建档、规律产前检查并住院分娩的单胎产妇临床资料,收集年龄、孕次、产次等,孕前BMI、孕早期血脂水平[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及游离脂肪酸(FFA)]等指标。依据新生儿是否发生早产分为早产组(n=98)和正常组(n=1088)。运用多因素logistic回归分析孕前BMI和孕早期血脂水平与新生儿早产发生的关系。结果:共纳入1186对母婴,新生儿早产98例(8.3%)。早产组年龄大于正常组,分娩孕周短于正常组,新生儿体质量小于正常组(均P<0.05);两组孕次、产次、新生儿性别、分娩方式及新生儿Apgar评分均未见差异(P>0.05)。早产组BMI<18.5kg/m~2占比(15.3%)低于正常组(25.0%),BMI≥24.0kg/m~2占比(20.4%)高于正常组(7.8%)(均P<0.05),两组18.5kg/m~2≤BMI<24.0kg/m~2占比无差异(P>0.05)。早产组孕早期TC、TG、LDL-C、FFA水平均高于正常组(均P<0.05),两组HDL-C水平无差异(P>0.05)。logistic回归分析显示,孕前BMI≥24.0kg/m~2、孕早期TG高水平、LDL-C高水平及FFA高水平是早产发生的独立风险因素(P>0.05)。结论:孕前BMI≥24.0kg/m~2,孕早期TC、TG及FFA水平升高是新生儿早产发生风险因素。Objective:To analyze the possible effects of the body mass index(BMI)and the blood lipid level of pregnant women during the first trimester of pregnancy on their premature delivery.Methods:From January 2022to December 2022,the clinical data of 1186singleton pregnant women who were registered in the obstetrics department of the hospital,and had regularly antenatal examined and hospitalized for delivery were selected as the research objects in this prospective cohort study.The general data,such as age,gravidity,parity and pre-pregnancy BMI,the levels of blood lipid during the first trimester of pregnancy,such as total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),low density protein(LDL-C)and free fatty acid(FFA)of these women were collected.The neonates of these women were divided into group A(98cases with preterm birth)and group B(1088 cases without preterm birth)according to whether the preterm birth occurred or not.Multivariate logistic regression was used to analyze the correlation between the pre-pregnancy BMI value and the blood lipid level of the women during the first trimester of pregnancy and their premature delivery.Results:A total of 1186mother and infant pairs were included in this study,among which,98(8.3%)newborns were preterm births.The age of the women in group A was significantly older than that of the women in group B.The gestational weeks of the women in group A at delivery were significantly shorter than that of the women in group B.The newborn weight in group A was significantly lower than that in group B(all P<0.05).There were no significant differences in the gravidity,the parity,the neonatal gender,the delivery mode and the neonatal Apgar score between the two groups(P>0.05).The proportion of the BMI<18.5kg/m^(2)(15.3%)of the women in group A was significantly lower than that(25.0%)of the women in group B,and the proportion of BMI≥24.0kg/m^(2)(20.4%)of the women in group A was significantly higher than that(7.8%)of the women in group B(all P<0.05),and there was no sign

关 键 词：早产 孕期体质指数 孕早期血脂水平 风险因素 

分 类 号：R714[医药卫生—妇产科学]