唐氏综合征筛查指标、血液流变学指标与HDP发生关系  

Correlation between the Down syndrome screening indexes and the hemorheological indexes women and their hypertensive disorder complicating pregnancy

作　　者：陈伶奕 胡瑜洁 郑敏珠 薛阳 周金英 CHEN Lingyi;HU Yujie;ZHENG Minzhu;XUE Yang;ZHOU Jinying(Hangzhou Maternal and Child Health Hospital,Hangzhou,Zhejiang Province,310012;Hangzhou Obstetrics and Gynecology Hospital,Hangzhou)

机构地区：[1]浙江省杭州市妇幼保健院,310012 [2]浙江省杭州市妇产科医院

出　　处：《中国计划生育学杂志》2024年第11期2653-2657,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨基于唐氏综合征筛查指标、血液流变学指标妊娠期高血压疾病(HDP)发生的危险因素。方法:回顾性选取2020年1月-2023年12月本院收治的80例HDP患者为HDP组,产前检查未合并HDP孕妇76例为对照组。对比两组唐氏综合征筛查指标及血液流变学指标,采用单因素及logistic多因素回归分析HDP发生危险因素,Spearman秩相关性分析唐氏筛查指标、血液流变学指标与HDP发生的相关性。结果:两组肥胖率、糖尿病史、HDP家族史、产前检查情况、负性情绪、活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、妊娠相关血浆蛋白A(PAPP-A)、β-人绒毛膜促性腺激素(β-hCG)、游离雌三醇(uE3)及甲胎蛋白(AFP)水平均有差异(P<0.05);多因素分析显示,肥胖、存在糖尿病史、HDP家族史、未定期产前检查、负性情绪,APTT、PT、TT、uE3、PAPP-A水平降低,AFP、β-hCG水平升高是HDP发生的独立危险因素(均P<0.05);Spearman相关性分析显示,APTT、PT、TT、uE3、PAPP-A水平与HDP发生呈负相关(r=-0.438,-0.452,-0.434,-0.478,-0.423,均P<0.05),AFP、β-hCG水平与HDP发生呈正相关(r=0.463,0.441,均P<0.05)。结论:唐氏综合征筛查指标血清uE3、AFP、PAPP-A、β-hCG,血液流变学指标APTT、PT、TT与HDP发生密切相关,临床应关注产前检查上述指标,以便采取相应防治措施降低HDP风险,改善妊娠结局。Objective:To analyze the risk factors of the hypertensive disorder complicating pregnancy(HDP)of pregnant women based on their indexes of Down's screening and hemorheology.Methods:80 pregnant women with HDP admitted to the hospital from January 2020 to December 2023 were selected in study group retrospectively,another 76 pregnant women without HDP who had received antenatal examination were selected in control group.The indexes of Down's screening and hemorheology of the women were compared between the two groups.Univariate and logistic multivariate regression analysis were used to analyze the risk factors of HDP of the women.Spearman rank correlation analysis was used to analyze the correlation between the indexes of Down's screening and hemorheology of the pregnant women and their HDP occurrence.Results:There were significant differences in the obesity rate,the history of diabetes,the family history of HDP,the prenatal examination situation,the negative emotions,the values of activated partial prothrombin time(APTT),prothrombin time(PT),thrombin time(TT)and pregnancy-associated plasma protein A(PAPP-A),and the levels of β-human chorionic gonadotropin(β-hCG),free estriol(uE3)and alpha fetoprotein(AFP)the women were compared between the two groups(P<0.05).Multivariate analysis showed that the obesity,the history of diabetes,the family history of HDP,the lack of regular prenatal examination,the negative emotions,the decreased values of APTT,PT,TT,uE3,and PAPP-A,and the increased levels of AFP and β-hCG of the women were the independent risk factors of their HDP occurrence(all P<0.05).Spearman correlation analysis showed that the levels of APTT,PT,TT,uE3and PAPP-A of the women were negatively correlated with their HDP occurrence(r=-0.438,-0.452,-0.434,-0.478,-0.423,all P<0.05).The levels of AFP and β-hCG of the women were positively correlated with their HDP occurrence(r=0.463,0.441,all P<0.05).Conclusion:The Down syndrome screening indicators,such as serum uE3,AFP,PAPP-A and β-hCG,and the hemorheological indi

关 键 词：妊娠期高血压疾病 唐氏综合征筛查指标 血液流变学指标 危险因素 相关性 

分 类 号：R714.5[医药卫生—妇产科学]