Research advances of nanomaterials for the acceleration of fracture healing  

作　　者：Mo Zhang Fan Xu Jingcheng Cao Qingqing Dou Juan Wang Jing Wang Lei Yang Wei Chen 

机构地区：[1]School of Pharmacy,Key Laboratory of Innovative Drug Development and Evaluation,Hebei Medical University,Shijiazhuang,050017,PR China [2]Department of Orthopaedic Surgery,The Third Hospital of Hebei Medical University,No.139 Ziqiang Road,Shijiazhuang,050051,PR China [3]Key Laboratory of Biomechanics of Hebei Province,Orthopaedic Research Institution of Hebei Province,No.139 Ziqiang Road,Shijiazhuang,050051,PR China [4]NHC Key Laboratory of Intelligent Orthopaedic Equipment,The Third Hospital of Hebei Medical University,No.139 Ziqiang Road,Shijiazhuang,050051,PR China [5]Center for Health Sciences and Engineering,Hebei Key Laboratory of Biomaterials and Smart Theranostics,School of Health Sciences and Biomedical Engineering,Hebei University of Technology,Tianjin,300131,PR China

出　　处：《Bioactive Materials》2024年第1期368-394,共27页生物活性材料（英文）

基　　金：the financial support from the Postdoctoral Fund of Hebei Medical University,Key Supported Projects of the Joint Fund of the National Natural Science Foundation of China(Grant No.U22A20357);National Key R&D Program of China(Grant No.2020YFC1107601);Chunyu Project Outstanding Youth Fund of Hebei Medical University(No.CYYQ2023004);the China Postdoctoral Science Foundation(No.2023M730914 and 2023TQ0103).

摘　　要：The bone fracture cases have been increasing yearly,accompanied by the increased number of patients experiencing non-union or delayed union after their bone fracture.Although clinical materials facilitate fracture healing(e.g.,metallic and composite materials),they cannot fulfill the requirements due to the slow degradation rate,limited osteogenic activity,inadequate osseointegration ability,and suboptimal mechanical properties.Since early 2000,nanomaterials successfully mimic the nanoscale features of bones and offer unique properties,receiving extensive attention.This paper reviews the achievements of nanomaterials in treating bone fracture(e.g.,the intrinsic properties of nanomaterials,nanomaterials for bone defect filling,and nanoscale drug delivery systems in treating fracture delayed union).Furthermore,we discuss the perspectives on the challenges and future directions of developing nanomaterials to accelerate fracture healing.

关 键 词：Fracture healing NANOMATERIALS Bone defect Delayed union NON-UNION Bone regeneration 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]