Biofabrication methods for reconstructing extracellular matrix mimetics  

作　　者：Abdellah Aazmi Duo Zhang Corrado Mazzaglia Mengfei Yu Zhen Wang Huayong Yang Yan Yan Shery Huang Liang Ma 

机构地区：[1]State Key Laboratory of Fluid Power and Mechatronic Systems,Zhejiang University,Hangzhou,310058,China [2]School of Mechanical Engineering,Zhejiang University,Hangzhou,310058,China [3]Department of Engineering,University of Cambridge,Cambridge,United Kingdom [4]School of Medicine,The Chinese University of Hong Kong,Shenzhen,Guangdong,51817,China [5]The Affiliated Stomatologic Hospital,School of Medicine,Zhejiang University,Hangzhou,310003,China [6]Center for Laboratory Medicine,Allergy Center,Department of Transfusion Medicine,Zhejiang Provincial People’s Hospital,Affiliated People’s Hospital,Hangzhou Medical College,Hangzhou,Zhejiang,310014,China

出　　处：《Bioactive Materials》2024年第1期475-496,共22页生物活性材料（英文）

基　　金：funding from National Key Research and Development Program of China(No.2018YFA0703000);The National Natural Science Foundation of China No.52275294 and supports from Zhejiang University Global Partnership Fund;the financial support from Chinese Scholar Councils(CSC)Scholarship fund.We would also like to thank Dr.Zhaoying Li and Dr.Elisabeth Lauren Gill for their essential contributions.

摘　　要：In the human body,almost all cells interact with extracellular matrices(ECMs),which have tissue and organ-specific compositions and architectures.These ECMs not only function as cellular scaffolds,providing structural support,but also play a crucial role in dynamically regulating various cellular functions.This comprehensive review delves into the examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical and biochemical properties of ECMs.We discuss the potential integration of these ECM-mimics into a range of physiological and pathological in vitro models,enhancing our understanding of cellular behavior and tissue organization.Lastly,we propose future research directions for ECM-mimics in the context of tissue engineering and organ-on-a-chip applications,offering potential advancements in therapeutic approaches and improved patient outcomes.

关 键 词：Extracellular matrix BIOFABRICATION Electrospinning BIOPRINTING Organ-on-a-Chip 

分 类 号：R318[医药卫生—生物医学工程]