Human foetal brain self-organises into long-term expanding organoids  

作　　者：Zhu A.ZZheng Wei Wang Fu M.Yang Wei Q.Liu Guo S.Han 

机构地区：[1]Institute of Translational Medicine,Shanghai University,Shanghai,China [2]Musculoskeletal Organoid Research Center,Shanghai University,Shanghai,China [3]School of Medicine,Shanghai University,Shanghai,China [4]Department of Neurosurgery,Shanghai Fourth People’s Hospital Affiliated to Tongji University,Shanghai,China [5]Clinical Research Center for Mental Disorders,Shanghai Pudong New Area Mental Health Center,School of Medicine,Tongji University,Shanghai,China

出　　处：《Biomaterials Translational》2024年第4期451-453,共3页生物材料转化电子杂志（英文）

基　　金：supported by the Foundation of National Center for Translational Medicine(Shanghai)SHU Branch(No.SUITM-202409).

摘　　要：Simulating human brain development accurately has the potential to improve our understanding of human brain development and various brain disorders.Although animal models play an indispensable role in the field of developmental neurobiology,inherent species differences limit their capacity to replicate the intricacies of specific human diseases.1 In light of these limitations,recent advancements in the technology of brain organoids present a promising avenue for investigating the development and functionality of the human brain.Regional brain organoids,such as those derived from dorsal and ventral forebrain,maintain their regional identity and recapitulate many aspects of early development,while whole brain organoids develop various discrete brain regions but may not fully replicate the regional specificity seen in vivo.

关 键 词：SPECIFICITY EXPANDING MAINTAIN 

分 类 号：R318.1[医药卫生—生物医学工程]