小儿社区获得性肺炎呼吸道病原体检测及外周血T淋巴细胞亚群特征分析  

Detection of respiratory pathogens and characteristics of peripheral blood T lymphocyte subsets in children with community-acquired pneumonia

作　　者：荣雨葳 黄斌[2] RONG Yu-wei;HUANG Bin(Department of Clinical Laboratory Medicine,Shenzhen Bao'an People's Hospital,Guangdong Shenzhen 518101)

机构地区：[1]深圳市宝安区人民医院检验科,广东深圳518101 [2]北京大学深圳医院重症医学科,广东深圳518000

出　　处：《医学检验与临床》2024年第9期39-42,共4页Medical Laboratory Science and Clinics

摘　　要：目的:分析小儿社区获得性肺炎(CAP)呼吸道病原体检测结果及不同病原体感染下患儿外周血T淋巴细胞亚群特征。方法:选取2019年1月-2021年2月本院接收的小儿CAP患者200例,所有患儿均行呼吸道病原检测,分析小儿CAP呼吸道病原体检测结果,并比较不同病原体感染下患儿外周血T淋巴细胞亚群特征。结果:检测结果显示,200例患儿中158例病原体检测呈阳性,阳性率为79.00%,共检出病原体325株,其中细菌175株(53.85%)、病毒103株(31.69%)、真菌25株(7.69%)、肺炎支原体22株(6.77%);婴儿组细菌、病毒、真菌检出率显著高于其他各组(P<0.05),学龄前期组肺炎支原体检出率显著高于其他各组(P<0.05);春冬检出病原菌较多,其中冬季组细菌、病毒、真菌检出率显著高于其他各组(P<0.05),夏季组肺炎支原体检出率显著高于其他各组(P<0.05);各组病原体感染患儿CD3CD4^(+)、CD3^(+)水平明显低于未检出病原组(P<0.05),各组病原体感染患儿CD3^(+)CD8^(+)、CD4^(+)/CD8^(+)水平明显低于未检出病原组(P<0.05);各组病原体感染患儿外周血T淋巴细胞亚群水平比较无明显差异(P>0.05)。结论:小儿CAP多发于低龄患儿,感染病原类型与儿童年龄、季节相关,感染后患儿机体存在一定程度免疫功能失调。将抗感染治疗与改善免疫功能相结合,可为治疗小儿CAP提供新思路。Objective:To analyze the detection results of respiratory pathogens in children with community acquired pneumonia(CAP)and the characteristics of peripheral blood T lymphocyte subsets in children infected with different pathogens.Methods:200 pediatric CAP patients admitted to our hospital from January 2019 to February 2021 were selected,and all patients underwent respiratory pathogen testing.The results of respiratory pathogen testing for pediatric CAP were analyzed,and the characteristics ofT lymphocyte subsets in the peripheral blood of the patients under dferent pathogen infections were compared.The results showed that 158 out of 200 children tested positive for pathogens,with a positive rate of 79.00%.A total of 325 strains of pathogens were detected,including 175 strains of bacteria(53.85%),103 strains of viruses(31.69%),25 strains of fungi(7.69%),and 22 strains of Mycoplasma pneumoniae(6.77%);The detection rate of bacteria,viruses,and fungi in the infant group was significantly higher than that in other groups(P<0.05),and the detection rate of Mycoplasma pneumoniae in the preschool group was significantly higher than that in other group(P<0.05);There are many pathogenic bacteria detected in spring and winter,with a significantly higher detection rate of bacteria,viruses,and fungi in the winter group compared to other groups(P<0.05),and a significantly higher detection rate of Mycoplasma pneumoniae in the summer group compared to other groups(P<0.05);The levels of CD3^(+),CD4t,and CD3^(+)in each group of pathogen infected children were significantly lower than those in the undetected pathogen group(P<0.05),and the levels of CD3^(+),CD8t,and CD4^(+)/CD8^(+)in each group of pathogen infected children were significantly lower than those in the undetected pathogen group(P<0.05);There is no significant difference in the levels of T lymphocyte subsets in the peripheral blood of children infected with pathogens among different groups(P>0.05).Conclusion:Pediatric CAP is more common in young children,and the type of i

关 键 词：小儿社区获得性肺炎 病原体检测 血T淋巴细胞亚群 

分 类 号：R725.6[医药卫生—儿科] R392[医药卫生—临床医学]