转录组学和蛋白组学在中药毒性机制研究中的应用进展  

Advances in the application of transcriptomics and proteomics in toxicity studies of traditional Chinese medicine

作　　者：赵灿灿 张建永 李晓飞 Zhao Cancan;Zhang Jianyong;Li Xiaofei(School of Basic Medicine,Zunyi Medical University,Zunyi Guizhou 563006,China;School of Pharmacy,Zunyi Medical University,Zunyi Guizhou 563006,China)

机构地区：[1]遵义医科大学基础医学院,贵州遵义563006 [2]遵义医科大学药学院,贵州遵义563006

出　　处：《遵义医科大学学报》2024年第11期1142-1150,共9页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:82260812)。

摘　　要：随着中药的普遍使用,其潜在的毒性风险也逐渐被人们所重视。目前中药毒性检测及其分子机制研究仍缺乏安全、高效、灵敏的技术体系。转录组学作为一门研究细胞内基因转录及其调控的学科,蛋白质组学作为研究生物体内蛋白质组成、结构、功能和相互作用的学科,均可为深入研究中药毒性提供了新视角和新方法。二者的联合应用可弥补因转录后调控、翻译效率等因素造成的基因表达与蛋白质表达之间的差异,可更全面地了解生物体在毒性机理下的分子变化,从分子层面更精确地解释毒性机制。本文综述了近年来转录组学和蛋白组学在中药毒性研究中的应用进展,旨在为中药的安全使用提供科学依据。With the widespread use of traditional Chinese medicine(TCM)in China,its potential toxic risks have gradually gained attention.There is a lack of safe,efficient,and sensitive technical systems for studying the toxicity detection and molecular mechanisms of TCM.Transcriptomics,which studies gene transcription and its regulation,and proteomics,which studies the composition,structure,function,and interactions of proteins in organisms,provide new perspectives and methods for the deep investigation of TCM toxicity.The combined application of the two can not only compensate for the differences between gene expression and protein expression caused by post-transcriptional regulation,translation efficiency,and other factors,but also provide a more comprehensive understanding of the molecular changes in organisms under toxic insults,allowing for a more precise study of toxic mechanisms at the molecular level.This article reviews recent research progress on the toxicity of TCM and the application and progress of transcriptomics and proteomics in studying the toxicity of TCM,aiming to provide a scientific basis for the safe use of TCM.

关 键 词：中药 毒性 转录组学 蛋白组学 组学联用 作用机制 

分 类 号：R383.3[医药卫生—医学寄生虫学]