奥美拉唑联合谷氨酰胺对上消化道出血患儿的疗效  

Efficacy of omeprazole combined with glutamine in children with upper gastrointestinal bleeding

作　　者：杜鑫 易贤红 李建木[1] 杨凡[1] 冯玲玲[1] 刘兴楼 DU Xin;YI Xianhong;LI Jianmu;YANG Fan;FENG Lingling;Liu Xinglou(Department of Pediatrics,the First People’s Hospital of Xiantao,Xiantao 433099,China;Department of Pediatrics,Wuhan Tongji Hospital,Wuhan 430030,China)

机构地区：[1]仙桃市第一人民医院儿科,仙桃433099 [2]武汉同济医院儿科,武汉430030

出　　处：《西北药学杂志》2024年第6期139-143,共5页Northwest Pharmaceutical Journal

基　　金：湖北省自然科学基金项目(编号:2020CFC895)。

摘　　要：目的探究奥美拉唑与谷氨酰胺联合治疗对上消化道出血患儿血小板活化功能的影响。方法选取收治的上消化道出血患儿100例,用随机数字表法分为对照组和联合组,各50例。对照组予以奥美拉唑静脉滴注,联合组在对照组治疗的基础上口服谷氨酰胺,2组均连续治疗4个疗程。比较2组的止血时间、大便潜血转阴时间、输血量和住院时间;比较2组治疗前后的血小板活化功能指标[血小板第4因子(platelet factor-4,PF4)、可溶性P选择素(P-selectin,CD62P)]变化、氧化应激指标[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)]变化;比较2组的临床疗效及不良反应发生情况。结果治疗后,联合组的止血时间、大便潜血转阴时间及住院时间较对照组明显缩短,输血量明显少于对照组(P<0.05);2组的PF4、CD62P水平均升高,且联合组显著高于对照组(P<0.05);2组的SOD水平均升高,MDA水平均降低,且联合组各水平的变化均更显著(P<0.05);联合组的治疗总有效率明显高于对照组(P<0.05),2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论奥美拉唑与谷氨酰胺联合治疗对上消化道出血患儿疗效显著,且安全性高,能有效改善患儿的血小板活化功能,抑制患儿的氧化应激反应,有利于缩短患儿的出血时间,促进患儿早日康复。Objective To investigate the effects of omeprazole and glutamine combined therapy on platelet activation in children with upper gastrointestinal bleeding.Methods 100 cases of children with upper gastrointestinal bleeding were selected and divided into a control group and a combined group according to random number table method,with 50 cases in each group.The control group was treated with intravenous infusion of omeprazole,and the combined group was treated with oral glutamine on the basis of the control group.The both groups were treated for 4 consecutive courses.The hemostatic time,fecal occult blood turning negative time,blood transfusion volume and hospital stay of the 2 groups were compared.The changes of platelet activation function indices[platelet factor 4(PF4)and soluble p-selectin(CD62P)]and oxidative stress indices[superoxide dismutase(SOD)and malondialdehyde(MDA)]were compared between the 2 groups before and after treatment.The clinical efficacy and adverse reactions of the 2 groups were also compared.Results After treatment,the hemostasis time,fecal occult blood conversion time and hospitalization time in the combined group were significantly shorter,and the amount of blood transfusion was significantly less than that in control group(P<0.05).After treatment,the levels of PF4 and CD62P in the 2 groups were increased,and the levels of PF4 and CD62P in the combined group were significantly higher than those in the control group(P<0.05).After treatment,the SOD level increased and MDA level decreased in both groups,and the changes of levels in the combined group were more significant than those in the control group(P<0.05).The total effective rate in the combined group was significantly higher than that in the control group(P<0.05),but there was no significant difference in the total incidence of adverse reactions between the 2 groups(P>0.05).Conclusion The combined treatment of omeprazole and glutamine has significant efficacy and high safety for children with upper gastrointestinal bleeding,which can e

关 键 词：奥美拉唑 谷氨酰胺 上消化道出血 血小板活化功能 氧化应激反应 安全性 

分 类 号：R975[医药卫生—药品]