多烯磷脂酰胆碱注射液联合异甘草酸镁注射液治疗药物性肝损伤的效果  

Effect of Polyene Phosphatidylcholine Injections combined with Magnesium Isoglycyrrhizinate Injections on drug-induced liver injury

作　　者：廖强 韩娟[2] 袁成雪 张瑞[1] 李文斌[1] 张剑[1] LIAO Qiang;HAN Juan;YUAN Chengxue;ZHANG Rui;LI Wenbin;ZHANG Jian(Department of Pharmacy,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Nephrology,Chengdu Second People’s Hospital,Chengdu 610000,China;Department of Gastroenterology,Shangjin Hospital,West ChinaHospital,Sichuan University,Chengdu 610000,China)

机构地区：[1]四川大学华西医院临床药学部(药剂科),成都610041 [2]成都市第二人民医院肾病内科,成都610000 [3]四川大学华西医院上锦医院消化内科,成都610000

出　　处：《西北药学杂志》2024年第6期149-153,共5页Northwest Pharmaceutical Journal

基　　金：四川省教育厅科研项目(编号:16ZB0534)。

摘　　要：目的探究多烯磷脂酰胆碱注射液联合异甘草酸镁注射液治疗药物性肝损伤(drug-induced liver injury,DILI)的临床效果及对患者肝功能的影响。方法选取DILI患者108例,随机分为观察组和对照组,每组54例。对照组使用异甘草酸镁注射液治疗,观察组使用多烯磷脂酰胆碱注射液联合异甘草酸镁注射液治疗,疗程均为4周。比较治疗后2组患者的临床表现消失时间和不良反应发生情况,并比较2组治疗前后的肝功能指标[丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin,TBiL)和碱性磷酸酶(alkaline phosphatase,ALP]、血清氧化应激指标[血清丙二醛(malonaldehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)和超氧化物歧化酶(superoxide dismutase,SOD)]及血清细胞因子[白细胞介素(interleukin,IL)-6、IL-1β和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平。结果观察组肝区胀痛、上腹部不适、食欲减退和乏力等临床表现消失时间均短于对照组(P<0.05);治疗后,2组的ALT、AST、TBiL、ALP、MDA、IL-6、IL-1β和TNF-α水平均降低,且观察组均低于对照组(P<0.05);观察组的不良反应发生率(12.95%)与对照组(9.25%)比较差异无统计学意义(P>0.05)。结论多烯磷脂酰胆碱联合异甘草酸镁注射液治疗DILI可有效促进患者的症状消退,并改善其肝功能,减轻炎症反应和提高抗氧化应激能力,且安全性良好。Objective To explore the clinical effect of Polyene Phosphatidylcholine Injections combined with Magnesium Isoglycyrrhizinate Injections in the treatment of drug-induced liver injury(DILI)and its influence on liver function.Methods 108 patients with DILI were selected and randomly divided into observation group and a control group,54 cases in each group.The control group was treated with Magnesium Isoglycyrrhizinate Injections,while the observation group was given Polyene Phosphatidylcholine Injections combined with Magnesium Isoglycyrrhizinate Injections.The both groups were treated for 4 weeks.The disappearance time of each clinical manifestation and the occurrence of adverse reactions were compared between the 2 groups after treatment.The liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBiL)and alkaline phosphatase(ALP)],serum oxidative stress indicators[serum malondialdehyde(MDA),glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)]and serum cytokines[interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)]were compared between the 2 groups before and after treatment.Results The disappearance times of clinical manifestations such as swelling pain in liver area,upper abdominal discomfort,loss of appetite and fatigue in the observation group were shorter than those in the control group(P<0.05).After treatment,the levels of ALT,AST,TBiL,ALP,MDA,IL-6,IL-1βand TNF-αin both groups were decreased,and the levels in the observation group were lower than those in the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the observation group(12.95%)and the control group(9.25%),P>0.05.Conclusion Polyene Phosphatidylcholine Injections combined with Magnesium Isoglycyrrhizinate Injections can effectively promote the symptom regression,improve the liver function,relieve the inflammatory response and enhance the antioxidant stress ability in patients with DILI,and it has good safety.

关 键 词：多烯磷脂酰胆碱注射液 异甘草酸镁注射液 药物性肝损伤 

分 类 号：R975[医药卫生—药品]