利托君对未足月胎膜早破患者髓系细胞触发受体-1和血清淀粉样蛋白A的影响  

Influence of ritodrine on triggering receptor expressed on myeloid cells-1 and serum amyloid A in patients with preterm premature rupture of membranes

作　　者：蔡晓立 罗欢 CAI Xiaoli;LUO Huan(Department of Gynecology,Yangtze River Shipping General Hospital,Wuhan 430014,China;Department of Gynecology,Wuhan Third Hospital,Wuhan 430074,China)

机构地区：[1]长江航运总医院妇科,武汉430014 [2]武汉市第三医院妇科,武汉430074

出　　处：《西北药学杂志》2024年第6期174-178,共5页Northwest Pharmaceutical Journal

基　　金：湖北省自然科学基金项目(编号:2019CFC841)。

摘　　要：目的探究盐酸利托君对未足月胎膜早破患者髓系细胞触发受体-1(triggering receptor expressed on myeloid cells-1,TREM-1)和血清淀粉样蛋白A(serum amyloid A,SAA)水平的影响。方法选取未足月胎膜早破患者120例,依据入院先后顺序分为对照组和观察组,各60例。对照组予以硫酸镁静脉滴注,观察组予以盐酸利托君治疗。比较2组产妇的围产期指标(宫缩抑制时间、孕周延长时间以及产后出血量)及2组产妇治疗前后的血清TREM-1和SAA水平,比较2组的妊娠结局、临床疗效和新生儿并发症发生情况。结果观察组的总有效率显著高于对照组(P<0.05);治疗后,观察组的宫缩抑制时间、产后出血量较对照组明显缩短(减少),孕周时间较对照组明显延长(P<0.05),新生儿出生体质量、Apgar评分均高于对照组(P<0.05),新生儿并发症的总发生率明显低于对照组(P<0.05);2组的血清TREM-1、SAA水平均降低,且观察组的各指标较对照组明显更低(P<0.05)。结论对未足月胎膜早破患者,采用盐酸利托君治疗能明显缩短宫缩时间,减少分娩时出血量,延长孕周时间,降低血清TREM-1、SAA水平,改善妊娠结局,疗效显著,安全性高。Objective To investigate the influence of ritodrine hydrochloride on triggering receptor-1(triggering receptor expressed on myeloid cells-1,TREM-1)and serum amyloid A(serum amyloid A,SAA)levels in patients with preterm premature rupture of membranes.Methods A total of 120 cases of preterm premature rupture of membranes were selected and divided into a control group(n=60)and an observation group(n=60)according to the order of admission.The control group was given intravenous infusion of magnesium sulfate,while the observation group was treated with ritodrine hydrochloride.The perinatal indexes(uterine inhibition time,gestational duration and postpartum blood loss)were compared between the 2 groups.The serum TREM-1 and SAA levels were compared between the 2 groups before and after treatment,and the pregnancy outcomes,clinical efficacy and neonatal complications were also observed and compared between the 2 groups.Results The total response rate in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the inhibition time of uterine contractions and postpartum blood loss in the observation group were significantly reduced compared with that in the control group,and the duration of gestational age was significantly prolonged(P<0.05).After treatment,the birth weight and Apgar score in observation group were higher than those in the control group(P<0.05).The total incidence of neonatal complications was significantly lower than that of the control group(P<0.05).After treatment,the serum TREM-1 and SAA levels in the 2 groups were decreased,and the indices in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Ritodrine hydrochloride treatment for preterm premature rupture of membranes can significantly shorten the time of uterine contractions,reduce the amount of blood loss during delivery,prolong the gestational period,reduce the level of serum TREM-1 and SAA,and improve the pregnancy outcome,with significant efficacy and high

关 键 词：盐酸利托君 硫酸镁 未足月胎膜早破 髓系细胞触发受体-1 血清淀粉样蛋白A 妊娠结局 

分 类 号：R984[医药卫生—药品]