替米沙坦联合西尼地平治疗原发性高血压的疗效  

Effect of telmisartan combined with cilnidipine on essential hypertension and on blood lipid metabolism

作　　者：印章 付永波 朱冬梅 凡洋 徐进林 YIN Zhang;FU Yongbo;ZHU Dongmei;FAN Yang;XU Jinin(Department of Cardiovascular Medicine,Xiantao First People’s Hospital Affiliated to Yangtze University,Xiantao 433000,China)

机构地区：[1]长江大学附属仙桃市第一人民医院心血管内科,仙桃433000

出　　处：《西北药学杂志》2024年第6期201-206,共6页Northwest Pharmaceutical Journal

基　　金：仙桃市卫生健康委员会项目(编号:WJ2021F099)。

摘　　要：目的探究替米沙坦联合西尼地平治疗原发性高血压的效果。方法选取100例原发性高血压患者作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组给予西尼地平治疗,观察组在对照组治疗的基础上给予替米沙坦治疗。比较治疗前后2组患者的血压[收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)]、血脂代谢指标[总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)]、氧化应激标志物[超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、晚期蛋白氧化产物(advanced oxidation protein products,AOPP)]、血管内皮功能因子[一氧化氮(nitric oxide,NO)、血管内皮素-1(endotheliin-1,ET-1)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)]的水平及不良反应的发生情况。结果治疗前,2组患者的血压、血脂代谢指标、氧化应激标志物、血管内皮功能因子比较,差异均无统计学意义(P<0.05)。治疗后,观察组的SBP、DBP水平均明显低于对照组(P<0.05);观察组的TC、TG、LDL-C水平均明显低于对照组,HDL-C水平明显高于对照组(P<0.05);观察组的MDA、AOPP水平均明显低于对照组,SOD水平明显高于对照组(P<0.05);观察组的NO、CGRP均明显高于对照组,ET-1水平明显低于对照组(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论替米沙坦联合西尼地平治疗原发性高血压患者疗效显著,可以更好地控制血压水平,改善血脂代谢,减轻氧化应激反应,调节血管内皮功能,安全性高。Objective To explore the application effect of telmisartan combined with cilnidipine on essential hypertension and its effect on blood lipid metabolism.Methods 100 patients with essential hypertension were randomly divided into a control group(n=50)and an observation group(n=50).The control group was given conventional treatment and cilnidipine,while the observation group was given telmisartan on the basis of the control group.The changes of blood pressure[systolic blood pressure(SBP),and diastolic blood pressure(DBP)],lipid metabolism[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),and low density lipoprotein cholesterol(LDL-C)],oxidative stress[superoxide dismutase(SOD),malondialdehyde(MDA),and advanced oxidation protein products(AOPP)],vascular endothelial function[nitric oxide(NO),endotheliin-1(ET-1),and calcitonin gene-related peptide(CGRP)]and adverse reactions were compared between the 2 groups.Results Compared with the control group,the SBP and DBP,the levels of TC,TG and LDL-C,MDA and AOPP,and ET-1 of the observation group were significantly lower(P<0.05),while the HDL-C,SOD,NO and CGRP were significantly higher(P<0.05).There was no significant difference in the total incidence of adverse reactions between the 2 groups.Conclusion Telmisartan combined with cilnidipine is beneficial to patients with essential hypertension.The combination can better control blood pressure,improve lipid metabolism,reduce oxidative stress reaction,and regulate vascular endothelial function,with high safety.

关 键 词：替米沙坦 西尼地平 原发性高血压 

分 类 号：R972[医药卫生—药品]